Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Proto-Oncogene Proteins p21(ras)"”.
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small cell lung cancer (NSCLC) (Zhou et al. Cancer Research, 2017; Zhou et al. Molecular Cancer Research, 2019). PCDH7 is frequently overexpressed in human lung cancers, significantly correlating with poor clinical …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small cell lung cancer (NSCLC) (Zhou et al. Cancer Research, 2017; Zhou et al. Molecular Cancer Research, 2019). PCDH7 is frequently overexpressed in human lung cancers, significantly correlating with poor clinical …
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Identification of Oncogenic KRAS-Associated Vulnerabilities in Non-Small Cell Lung Cancer
Activating mutations in KRAS are frequently involved in the pathogenesis of non-small cell lung cancer (NSCLC), the disease responsible for the most cancer-related deaths in the US. Despite intensive efforts to develop drugs that directly interfere with KRAS activity over the past decade, no …
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ADAP1 Promotes Latent HIV-1 Reactivation by Tuning the KRAS-ERK-AP-1 Signaling-Transcriptional Axis
… directly stimulates the GTPase activity of KRAS to amplify CD4+ T cell signaling through targeted activation of ERK-AP-1 axis. In primary CD4+ T cells which I have genetically ablated ADAP1, I show loss of ADAP1 function blunts gene expression programs in response to stimulation thereby …