Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Proto-Oncogene Proteins"”.
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Deciphering AXL-Driven Molecular Mechanisms of EMT
Pages xviii-xix are misnumbered as pages xix-xx.
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Evaluation of Chronic RalGTPase Activation as a Core Specifier of Oncogenic Transformation
… tumorigenicity of cancers that are driven by oncogenes other than Ras. In order to begin to understand how the Ral pathway may be chronically engaged in diverse oncogenic backgrounds, we further examined the expression of RalGEFs in a variety of cells derived from different tissue origin. Our …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small cell lung cancer (NSCLC) (Zhou et al. Cancer Research, 2017; Zhou et al. Molecular Cancer Research, 2019). PCDH7 is frequently overexpressed in human lung cancers, significantly correlating with poor clinical …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small cell lung cancer (NSCLC) (Zhou et al. Cancer Research, 2017; Zhou et al. Molecular Cancer Research, 2019). PCDH7 is frequently overexpressed in human lung cancers, significantly correlating with poor clinical …
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Validation of AXL as a Therapeutic Target in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDA), a leading cause of cancer-related death in the US, has a high metastatic rate that is associated with persistent immune suppression. AXL, a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family, has been identified as a critical factor that …
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Novel Functions of the Transcription Factor Aryl Hydrocarbon Receptor (AHR) and Its Tryptophan-Derived Ligands in Cancer Cells
… reprogramming of cancer cells, focusing on the proto-oncogene MYC and the aryl hydrocarbon receptor (AHR). The role of MYC in regulating tryptophan (Trp) metabolism was investigated in colon and liver cancer cells using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). …
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Molecular Mechanisms Underlying Innate Immune Kinase TBK1-Driven Oncogenic Transformation
… immune response, re-exposure to glucose, or oncogene activation, TBK1 is recruited to the exocyst, where it activates AKT. In cells lacking TBK1, insulin activates AKT normally, but AKT activation by these exocyst-dependent mechanisms is impaired. Discovery and characterization of a …
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Molecular Regulation of Direct Cardiac Reprogramming
… were 1) to optimize the cardiac reprogramming protocol by increasing the efficiency; and 2) to decipher molecular mechanisms of cardiac reprogramming using the information obtained from the optimization process. To improve the efficiency of reprogramming fibroblasts to iCMs by cardiac …
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Molecular Players in Lupus: Leads from Proteomic Screens
Systemic Lupus Erythematosus is a multifactorial systemic autoimmune disorder marked by anti-nuclear antibodies (ANA), rashes and photosensitivity, joint inflammation, nephritis, and other clinical criteria. SLE develops through the breakdown of three major checkpoints: adaptive immune tolerance, …
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Epithelial Tubular Fusion, Measuring Interconnection, and the Quest for Solving the Continuity Problem
The formation of functional epithelial tubules is a central feature of many organ systems. Although it has been well-studied how epithelial cells form tubules, it is not well understood how tubules and related epithelial micro-tissues such as spheroids and organoids interconnect with each other to …
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Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
… cytoplasmic tyrosines of the EpoR. Signaling proteins bind these phosphotyrosines through SH2 domains, leading to the survival and proliferation of erythroid progenitor cells and the differentiation of these progenitors into mature erythrocytes. Therefore, EpoR signaling is essential for red …
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Identification and Characterization of a Selective Inhibitor of the PIM-1 Kinase
<p>The PIM-1 kinase is a serine/threonine kinase that has been implicated in the development of many human cancers, including leukemias, lymphomas, and prostate cancer. We have endeavored to identify and characterize a selective inhibitor of the PIM- 1 kinase. Such an inhibitor would have utility …
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Investigating the Role of Complex I Loss in Thyroid Tumorigenesis
Changes in cellular metabolism are considered one of the hallmarks of cancer. In 1924, Otto Warburg initially posited that defects in cellular respiration drive tumorigenesis after observing that tumor cells often perform aerobic glycolysis in culture. Since then, multiple studies have demonstrated …
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Oncogene-Induced Signaling Heterogeneity in Lung Cancer
… has identified 138 frequently occurring driver oncogenes and tumor suppressor genes in lung cancer. Currently, only 15 of these genes can be targeted therapeutically. Study of downstream signaling alterations of these oncogenes and tumor suppressor genes may identify novel therapeutic targets. …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… elimination, suggesting that these autism-linked proteins coordinate transcriptional and translational control of common transcripts to mediate proper synaptic connectivity. Using high throughput sequencing of RNA isolated by cross-linking immunoprecipitation (HITS-CLIP) of FMRP, I find a large …
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Loss of TBK1 Kinase Function Improves Disease Outcome in Pancreatic Cancer and Metabolic Syndrome
Aberrant expression and activity of TANK binding kinase 1 (TBK1) has been observed in numerous diseases. Here I've identified novel functions for TBK1 in pancreatic ductal adenocarcinoma (PDA) and in metabolic syndrome that promote disease progression. Activating mutations in KRAS are present in …
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Identification of Oncogenic KRAS-Associated Vulnerabilities in Non-Small Cell Lung Cancer
Activating mutations in KRAS are frequently involved in the pathogenesis of non-small cell lung cancer (NSCLC), the disease responsible for the most cancer-related deaths in the US. Despite intensive efforts to develop drugs that directly interfere with KRAS activity over the past decade, no …
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B-Cell Adapter for Phosphoinositide 3-Kinase Is a Signaling Adapter in the Toll-Like Receptor/Interleukin-1 Receptor Superfamily
Toll-like receptor (TLR)/Interleukin-1 receptor (IL1R) superfamily members share signaling components and (with the exception of TLR3) depend on the adapter myeloid differentiation primary response gene 88 (MyD88) for engagement of downstream pathways. Signals from the receptor to the adapter are …
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AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC Through Expansion of TCF1+ CD8 T Cells
Mutations in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB) for unknown reasons. We found that introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas driven by mutant Kras and Trp53 (KP) resulted in …
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Proteomic Discovery of Functionally Important Pathways in Myocardial Ischemia-Reperfusion Injury
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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