Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 886 for “"Proteomic"”.
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Transcriptomic and proteomic dysregulation in neuropsychiatric disorders
… We used a combination of transcriptomic and proteomic methods, leveraging large RNA-Seq and microarray datasets to circumvent issues with power for the proposed analyses. A literature summary on previously identified transcriptomic and proteomic dysregulations in neuropsychiatric disorders, …
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Proteomic Analysis of Mammary Epithelial Cell Development
<p>In this set of studies, a proteomic approach was used to investigate the protein profile of the mammary epithelial cell (MEC) through different stages of mammary development. The HC11 cell line was used to investigate protein changes between undifferentiated and differentiated MEC, which …
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Sources of Variability in a Proteomic Experiment
The study of proteomics holds the hope for detecting serious diseases earlier than is currently possible by analyzing blood samples in a mass spectrometer. Unfortunately, the statistics involved in comparing a control group to a diseased group are not trivial, and these difficulties have led others …
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Molecular Players in Lupus: Leads from Proteomic Screens
… urine improve diagnosis and treatment of SLE. Proteomic screens identify such markers and provide important clues about disease pathogenesis. We have discovered that soluble Axl receptor tyrosine kinase, the Wnt/β-catenin pathway-related factors, and rare fibrinogen alpha chain variant A-α-E …
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Comparative proteomic analysis of Australian epidemic Bordetella pertussis
… of the host’s immunisation background. Proteomic methods for secretome and surfaceome analysis was established. The B. pertussis secretome was characterised in Stainer-Scholte (SS) and Thalen-IJessel (THIJS) media. Ten virulence proteins were detected uniquely in THIJS while an …
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Exploring Histone Modifying Complexes with a Proteomic Approach
Der SET-Bereich befindet sich unter den verschiedenen Proteinsequenzbereichen, die mit epigentischer Regulation hauptsächlich durch die Präsenz von Trihtorax (trxG) und Polycomb (PcG) Gruppen von Chromatinmodifikatoren in Zusammenhang gebracht werden. Nach der Entdeckung des ersten SET-Bereichs vor …
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Proteomic analysis of genetically stratified grade-I meningioma
… stratified meningioma by characterising the proteomic landscape. Materials and methods: Frozen meningioma tissue samples were stratified according to mutational background: AKT1E17K/TRAF7, KLF4K409Q/TRAF7 and NF2-/-. For global proteomics, proteins were fractionated by SDS-PAGE followed by …
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Proteomic Investigation of Salivary Biomarkers in Periodontal Diseases
Introduction: The aim of the study was to investigate novel biomarkers of periodontal disease present in GCF and saliva. -- Methods: The identities of specific putative biomarkers identified by SELDI-TOF MS were confirmed using 1-D PAGE coupled with LC-MS/MS. These biomarkers were then tested using …
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Proteomic identification of putative biomarkers of radiotherapy resistance
… of radiotherapy response using comparative proteomic platforms to study radioresistant cell line models. The identification of such biomarkers will enable radiotherapy to be tailored on an individual patient basis and hence increase treatment efficacy.MethodsSeven radioresistant (RR) cell …
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Messenger Ribonucleoprotein (Mrnp) Complexes: Proteomic and Functional Analysis
We provided the evidence that both microtubules and actin filaments are required for the proper localization of FMRP-RNP particles. Furthermore, FMRP associates with both microtubule- and actin-based motors, kinesin-1 and myosin Va. In order to unambiguously identify the detailed molecular …
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Proteomic Analysis of Three Dimensional Organotypic Liver Models
… communication processes. Bottom-up shotgun proteomic analysis of the hepatic cells can lend insight into such processes. This technique employs liquid chromatography-tandem mass spectrometry (LC-MS/MS) for relative quantification of protein abundances by measuring intensities of their …
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Proteomic Map of ER+ Breast Cancer Cell Cycle
… at this point. We developed a large-scale proteomics strategy to enable the comparison of MCF-7 ER+ (cancer) and MCF-10A (non-tumorigenic) epithelial breast cells. Samples were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS) followed by a label-free quantitation …
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QUANTITATIVE PROTEOMIC APPROACHES TO STUDY DRUG MECHANISM OF ACTION
… and more importantly in clinical studies. Chemoproteomic approaches, taking advantage of the use of chemical probes, provide powerful tools to analyze binding characteristics between small molecules and proteins and validate the mode of action of these drug candidates. Click chemistry is a …
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PROTEOMIC ANALYSIS OF TWO DIFFERENT STATES OF NAEGLERIA FOWLERI
… The purpose of this study is to create a proteomic signature map using two-dimensional gel electrophoresis (2-D gel) and recommend a subset of proteins that may be directly linked to the pathogenic state of N. fowleri. Replicates of 2-D Gels were created for both strains of N. fowleri and …
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Proteomic Analysis Delineates the Signaling Networks of Plasmodium falciparum
… provided the foundation for quantitative phosphoproteomic analysis of kinase negative mutants to understand their function, 4) provided a major step towards defining kinase-substrate pairs operative within parasite*s signaling networks, and 5) generated a preliminary interactome for PfPK6.
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Proteome-Seq: Sequencing-Based Readout Of Proteomic Analytical Assay
… posing a significant challenge to existing proteomics methodologies. Even cutting-edge proteomics methods often encounter trade-offs between sensitivity, target number and the ability to detect low abundance proteins within single cells. This suggests a gap in our understanding of cellular …
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A Global and Targeted Proteomic Investigation of Aspergillus fumigatus
… and, less frequently, in immunocompetent hosts. Proteomic investigation of A. fumigatus has the potential to enable global analysis of protein expression, identify potential targets for vaccine or diagnostic tool development, and characterise system-wide responses to external stimuli. …
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A neurophysiological and proteomic study of cognitive enhancing strategies
… are investigated using neurophysiological and proteomic approaches. The effects of two classes of putatively cognitive enhancing drugs on emergent network oscillatory activities in hippocampal slices are investigated. The effect of an enriched environment, which causes an improvement in …
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A Proteomic Analysis of Differentiation in the Mammary Epithelium
<p>While a great deal is known about the changing hormonal environment and the structural development of the mammary gland from pregnancy to lactation, very little is known about the molecular mechanisms governing differentiation of the mammary epithelium into a milk-secreting phenotype. It is …
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