Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Proteolipid protein"”.
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Transgenic complementation of rumpshaker with wild type proteolipid protein
Mutations in the x-linked myelin proteolipid protein 1 gene (PLP1) cause the heterogeneous syndromes of Pelizaeus Merzbacher disease (PMD) and Spastic paraplegia type 2(SPG2) in man (Hudson et al., 2004). A single base change mutation in our spontaneous mouse model rumpshaker (Plpjp-rsh)(Ile186Thr) …
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Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis
… encoding the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in multiple sclerosis, to induce tolerance and protect against experimental autoimmune encephalomyelitis (EAE) was assessed. Unexpectedly, mice vaccinated with MOG-DNA develop an exacerbated form of …
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Design of Antigen-Specific Immunotherapies Through Modulation of Peripheral Tolerance Pathways
… dexamethasone (DEX) to the peptide autoantigen proteolipid protein (PLP139-151). Further studies into the disruption of co-stimulatory signals in EAE revealed a protective role for the programmed cell death 1 (PD-1) pathway, and antagonism of natural receptor engagement resulted in cellular …
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The effects of increased Plp1 gene dosage on expression and processing of myelin proteins
Mutations in proteolipid protein 1 (PLP1), an X-linked gene causes Pelizaeus-Merzbacher disease (PMD) in humans. The most frequent cause of PMD is the duplication of PLP1, which encodes the major myelin membrane protein of the human CNS. The #66 transgenic mice with extra copies of the wild type …
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Intestinal delivery of heterologous peptides with lactobacilli
… were developed as a tool to deliver heterologous protein into the gastrointestinal tract. Lactobacillus spp. are a potential delivery vehicle for oral antigens because of their generally regarded as safe (GRAS) status, ability to persist in the acidic environment of human gastrointestinal tract …
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Autoregulatory CD8 T-Cells Modulate CNS Autoimmune Disease by Targeting Encephalitogenic CD4 T-Cells
… have observed that myelin oligodendrocyte glycoprotein peptide (MOG₃₅₋₅₅)-specific CD8 T-cells do not mediate EAE, but in fact are capable of suppressing both de novo and established clinical disease. Corroborating these data, CD8-/- C57BL/6 mice are now shown to exhibit a more severe EAE. …
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Application Of Magnetic Resonance Imaging To Understanding The Pathogenesis Of The X-Linked Leukodystrophy Pelizaeus-Merzbacher Disease
… is synthesized by Schwann cells. In the CNS, Proteolipid protein 1 (PLP1), an integral membrane protein, is the major protein component of myelin, constituting ~50% of myelin protein. Mutations of the PLP1 gene in man cause a spectrum of neurological disease, ranging from the severe …