Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 128 for “"Proteoglycans"”.
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Vascular endothelial cell-surface proteoglycans
… cause noticeable changes in the cell surface proteoglycans synthesized by bovine aortic endothelial cells. This discrepancy suggested that the observed differences in cell-surface proteoglycan profiles cannot be ascribed to any specific single constituent of the extracellular matrix but that …
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Circulating proteoglycans and glycosaminoglycans during critical illness
… Important components of the glycocalyx are the proteoglycans with their attached glycosaminoglycans. At this location these molecules contribute to the adhesion and transport of leucocytes to inflamed tissue, the anticoagulation as well as the transport of fluid across the vessel wall. All these …
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Structure and metabolism of bovine aortic proteoglycans
… namely covalently bound to protein to form proteoglycans. There are numerous factors that make arterial proteoglycans difficult to study, such as their relatively low concentration in the tissue a s compared to cartilaginous tissue, and their association with the fibrous elements of the …
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Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)
<p>We have previously identified a heparan sulfate proteoglycan (HSPG), Syndecan-1 (SDC1), as a key effector for pancreatic ductal adenocarcinoma (PDAC) progression whose surface expression is driven by KRAS*. By leveraging various PDAC models, we found that surface SDC1 expression was initially …
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Glycosaminoglycans and proteoglycans in the developing rat brain
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Expression and function of proteoglycans in the nervous system
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Electroextraction of proteoglycans from calf articular cartilage in vitro
Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1989.
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The Role for Proteoglycans in Regulating Embryonic Patterning and Morphogenesis
… extracellular space through interactions with proteoglycans. Proteoglycans are high molecular-weight proteins consisting of a core protein with covalently linked glycosasminoglycan (GAG) sidechains, which are thought to mediate proteoglycan-ligand interactions. UDP-glucose dehydrogenase (Ugdh) …
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Functions of small leucine-rich repeat proteoglycans in connective tissues
… the cells secrete small leucine-rich repeat proteoglycans (SLRPs) that bind to collagen and influence its fibril formation. In this manner, fibromodulin - one of the SLRPs - can alter intermolecular cross-linking of collagen, which has long-term implications for the structural integrity of …
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Biosynthesis and degradation of proteoglycans in cultured smooth muscle cells
… synthesize and secrete radioactively labelled proteoglycans into two distinct extracellular compartments, the pericellular (cell surface/matrix layer) and the culture medium (extracellular). Cultures grown in the presence of ascorbic acid synthesize proteoglycans that are more highly sulphated …
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Role of the interaction of proHB-EGF with heparan sulfate proteoglycans
… possesses the ability to bind heparan sulfate proteoglycans (HSPGs). The interaction of HB-EGF with HSPGs has been previously studied only with the soluble (autocrine/paracrine) form of the protein (sHB-EGF), produced after proteolytic cleavage of the transmembrane form (proHB-EGF) from the …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… sAPL-1 to its target receptors. Heparin sulfate proteoglycans (HSPGs), such as LON-2 glypican and UNC-52 perlecan, are likely candidates for the ECM proteins that interact and guide sAPL-1. The disruption of APL-1 causes phenotypical changes, including in learning, reproduction, and memory; these …
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The role of heparan sulfate proteoglycans and heparanase in the control of vascular remodeling
… through increased production of heparan sulfate proteoglycans. Using inhibitors to p38 MAPK and ERK, we showed that activation of both of these pathways was essential for load-induced heparan sulfate production, TGF-,f1 activation, smad-2 activation and increased FGF-2 uptake. Further, we exposed …
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REGULATED UPTAKE OF BIOPOLYMERS Role of cell surface proteoglycans Implications for drug and gene delivery
… and microbes. This thesis deals with the role of proteoglycans in cellular internalization of charged biopolymers, i.e. the polyamine family of growth factors, HIV-Tat peptide, antimicrobial peptides, and nucleic acids. The presented findings bring proteoglycans into focus as a general …
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In vitro detection of cues that guide thalamocortical development : a role for chondroitin sulfate proteoglycans
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1996.
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