Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Proteoglycan-4"”.
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Proteoglycan-4 in Equine Joint Disease, Exercise, and in vitro Cartilage Repair
Proteoglycan-4 (PRG4) and hyaluronan (HA) are biological macromolecules with varied and diverse functions distributed throughout the body. In synovial fluid (SF), PRG4 and HA provide independent and synergistic contributions to tissue health and cartilage boundary lubrication. The biological …
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The behavior of rotator cuff tendon cells in three-dimensional culture
… protein (SZP), which is expressed by the gene, proteoglycan 4 (PRG4) may play a role in joint and intrafascicular lubrication. Studies have shown that a smooth muscle actin isoform (SMA), which plays a role in the contraction of smooth muscle cells, is expressed in the rotator cuff tendon cells. …
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PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis
… regulating inflammatory pathways in macrophages. Proteoglycan 4 (PRG4) and its receptor CD44 and its transducer PP2A signaling axis play a biologically significant role in regulating urate crystal inflammation.</p> <p><br /><strong>Methods</strong>: Monocytes and macrophages were primed with TLR2 …
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Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
… of synovial fibrosis. Synoviocytes produce proteoglycan-4 (PRG4; lubricin), a heavily glycosylated mucinous glycoprotein, and hyaluronic acid (HA). Both PRG4 and HA compete for binding to the CD44 receptor. Furthermore, rhPRG4 binds to TLR2 and TLR4 and acts as an antagonist to prevent TLR2 …
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Antibody engineering to evaluate binding, internalisation, and intracellular routing of tumour-targeting fusion proteins
… fragment (scFv) specific to chondroitin sulphate proteoglycan 4 (CSPG4), a tumour-associated antigen often overexpressed in TNBC. The scFv antibody derivative was genetically fused to a SNAP-tag, enabling stable and site-specific conjugation of the scFv to diagnostic and therapeutic substrates. To …
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Development of SNAP-tag based fusion proteins as novel auristatin F-containing immunoconjugates and photoimmunotheranostics in the detection and treatment of triple-negative breast cancer
… predictive potential for chondroitin sulfate proteoglycan 4 (CSPG4), CD44 and aspartate (aspartyl/asparaginyl) β-hydroxylase (ASPH)-positive TNBC cells, (2) generate functional recombinant ADC formulations as robust delivery systems carrying the antimitotic drug monomethyl auristatin F …