Global ETD Search
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Showing 1 to 4 of 4 for “"Proteoform"”.
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Complex Proteoform Identification Using Top-Down Mass Spectrometry
Proteoforms are distinct protein molecule forms created by variations in genes, gene expression, and other biological processes. Many proteoforms contain multiple primary structural alterations, including amino acid substitutions, terminal truncations, and posttranslational modifications. These …
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An investigation of proteoforms in health and disease using peptide-level readouts
… disease, we must seek a deeper understanding of proteoforms - the molecular variants of canonical proteins. Although humans have around 20,000 protein-coding genes, millions of proteoforms arise through mutations, splicing, and post-translational modifications. My thesis work focuses on two …
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Interrogating annotated protein coding regions for hitherto undetected translation
… method enables discovery of not yet annotated proteoforms and translated open reading frames (ORFs), even ones that are hidden in annotated protein coding regions. Here we employed the Ribo-seq data together with comparative genomics analysis in order to discover non-AUG initiated proteoforms …
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Caratterizzazione proteomica di fluidi e tessuti in diverse condizioni fisio-patologiche
… (BPI fold-containing family A member 1, two proteoforms of annexin A1, and keratin type 1 cytoskeletal 13), and several over-expressed proteins in adults (fatty acid-binding protein, S100A6, S100A7, two proteoforms of S100A9, several proteoforms of prolactin-inducible protein, Ig kappa chain, …