Global ETD Search
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Showing 1 to 2 of 2 for “"Proteintyrosinphosphatase"”.
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Das Interaktom der SH2-Domänen der Proteintyrosinphosphatase SHP2 und ihren krankheitsrelevanten Mutanten
The protein tyrosine phosphatase SHP2 is a common regulator of cytokine, growth factor signaling and has been shown to influence cell survival, proliferation and differentiation by regulation of MAP Kinase, Jak/STAT and PI3K pathways. Structurally SHP2 consists of two SH2 domains, a catalytically …
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Funktion der Protein-Tyrosin-Phosphatase SHP2 und des feedback-Inhibitors SOCS3 in der IL-6-Signaltransduktion
Interleukin-6 signals through a hexameric receptor complex composed of IL-6, the IL-6 receptor a and gp130. The intracellular region of gp130 is associated with the Janus kinases Jak1, Jak2 and Tyk2. Additionally, the intracellular part of gp130 displays six tyrosine motifs. The four membrane …