Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Proteins--Synthesis"”.
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Bio-inspired optimization & sampling technique for side-chain packing in MCCE
The prediction of proteins' conformation helps to understand their exhibited functions, allows for modeling and allows for the possible synthesis of the studied protein. Our research is focused on a sub-problem of protein folding known as side-chain packing. Its computational complexity has been …
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Leucyl-tRNA synthetase: dynamic subcellular relocalization and drug resistance mechanism
… to setting the genetic code during protein synthesis by charging tRNA with a specific amino acid. As such, they have been selected by the pharmaceutical industries as optimal targets. A new class of antimicrobial benzoxaborole compounds was identified as a potent inhibitor of leucyl-tRNA …
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Elucidating the role of eukaryotic initiation factor 5B (eIF5B) in non-canonical translation initiation
Cap-dependent translation drives the global synthesis of proteins. Under stress conditions global protein production is attenuated, yet the translation of ATF4 is upregulated through uORF- mediated translation initiation. eIF5B has been shown to deliver initiator-tRNA during non-canonical …
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Der Transkriptionsfaktor FKHR interagiert mit STAT-Faktoren und verstärkt die IL-6-Signaltransduktion
… proliferation but on the other hand reduce the synthesis of acute phase proteins in hepatocytes. This thesis will give a possible reason for this observation. An important pathway of signal transduction of growth factors depends on the activation of PI3 kinase and the ProteinkinaseB (PkB). …
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Retroviral-Medicated Transfer of Suppressor tRNA Genes Into Human Cells
Nonsense mutations in protein genes have been associated with a variety of human diseases. A useful therapeutic approach to correct such mutations may be to introduce genes expressing suppressor tRNA that recognize the premature stop codon, insert the appropriate amino acid, and allow translation …
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Toward understanding the function of the universally conserved GTPase HflX
… in the essential cellular process of protein synthesis, a role for YihA, YchF and HflX in this process has only recently been suggested. Here, a detailed kinetic analysis examining the interaction between HflX and its cellular partners is described. 50S and 70S ribosomal particles function as …
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The Mycobacterium smegmatis "Proteome" : effects of growth phase on total protein synthesis and on the response to heat shock
… of Mycobacterium smegmatis on total protein synthesis and on the heat shock response was investigated. De novo protein synthesis was monitored by labelling with 35 [S]methionine and the protein expression profiles analysed using one- and/two-dimensional polyacrylamide gel electrophoresis, …
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The development and application of mass-spectrometry-based tools to monitor proteome remodeling in microbes
… a highly orchestrated combination of regulated proteins synthesis, degradation, and modification, each contributing to the overall goal of matching the capacity of the expressed proteome to the demands of the sensed environment. Although each pathway will contribute, ultimately, whether cells …
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Insulin-mediated inhibition of tyrosinase activity and protein synthesis in melanoma cell cultures
… may be caused by a general reduction in protein synthesis due to insulin treatment.
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Studies on the mechanisms that contribute to the endoplasmic reticulum quality control system in Saccharomyces cerevisiae
… a quality control system that ensures that only proteins that have attained a native conformation are deployed to other destinations in the cell. In order to gain insight into the mechanisms that encompass the quality control system, two studies were conducted. First, I tested whether the host of …
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Strategies of overexpressing retinoid X receptor and pregnane x receptor for functional studies
… In addition to RXR and PXR there are other proteins involved in the RXR/PXR signaling pathway. Many proteins involved in this pathway are still unknown. This study documents the production of RXR and PXR in a bacterial recombinant fusion system. These proteins were expressed in a system that …
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The Role of Initiation Factor Dynamics in Translation Initiation
… reactions, ribosome-catalyzed protein synthesis, or translation, can be divided into initiation, elongation, and termination stages. Initiation is the rate-limiting stage of translation and a critical site for translational control of gene expression. Throughout all stages of protein …
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Generation of A L. Hesperus embryonic cDNA library for the isolation of genes involved in early pattern formation
… high evolutionary conservation of Hox and Pax proteins, I hypothesize that arachnids also use this system to organize their body pattern. To enable studies of the Westem black widow spider, Latrodectus hesperus, an embryonic eDNA library and a fixation protocol were developed for L. hesperus …
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