Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Proteins--Structure"”.
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Computational studies of membrane proteins: Structure, function and dynamics
Ion channels are membrane proteins that regulate the flow of ions across the cell membrane. These channels open in response to changes in electrostatic potential across the cell membrane or binding of small molecules to the channels and allow the passage of specific ions through their conduction …
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NMR-Based Characterization of Proteins: Structure, Dynamics and Binding Interfaces of Influenza A's M1
Biomolecular structure, dynamics and interactions are fundamental for understanding how living systems operate at atomic scale. Proteins and nucleic acids carry out most processes essential to life, and they are equally central to the molecular mechanisms underlying disease. Addressing major …
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Automated and accurate description of protein structure -- from secondary to tertiary structure
<p>The automated protein structure analysis (APSA) has been developed that describes protein structure via its backbone in a novel way. APSA generates a smooth line for the backbone which is completely described using curvature κ and torsion τ as a function of arc lengths. Diagrams of κ(s) and τ(s) …
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Computational Approaches to Predict Effect of Epigenetic Modifications on Transcriptional Regulation of Gene Expression
… in gene expression regulation where the structure of the DNA remains unaltered. It is a heritable and reversible modification and often involves addition or deletion of certain chemical compounds to the DNA. Histone modification is an epigenetic change that involves alteration of the …
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Targeting PfUCHL3 Using Chemically Constrained Peptides
… inhibitory peptide’s were shown to stabilise the proteins structure upon binding and increase the melting temperature. Work is currently underway to determine the cell permeability properties of the peptides and their ability to kill *Plasmodium* parasites *in vivo* with the long-term aim of …
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Evolution of protein structure function
Proteins are generated as a result of millions of evolutionary experiments over a billion years. These experiments are constrained by proteins structure and function. Investigating genomics data is a natural way for mining these constraints to address long-standing biological challenges. In this …
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Topology and geometry-based methods for quantifying the complexity of protein structures
… systems of filaments, such as those formed by proteins. In this dissertation we employ tools from knot theory in combination with available experimental data and molecular simulations to analyze the topological complexity of tau proteins. These proteins are involved in a class of …
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On the role of conformational flexibility in viral fusion mechanisms - fusion by disorder
… viruses infect cells through the use of fusion proteins, surface proteins which are responsible for fusing the viral and host membranes through large scale conformational transitions. Although pre-fusion and post-fusion structures have been experimentally determined for many viral fusion …
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Solid State NMR Relaxation Studies of Triosephosphate Isomerase
Both protein structure and dynamics are essential to understanding biological function. NMR is a powerful technique for the observation of protein dynamics in that dynamics can be observed site-specifically over a wide range of timescales from picoseconds to seconds. Spin relaxation measurements, …
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Experimental and Computational Advancements in Peptidomimetic Ligand Discovery
… specificity due to a wide variety of potential structures. At the same time, discovery tools for finding peptides that modify PPIs have evolved, including advances in affinity selection techniques and combinatorial chemistry. Specifically, the usage of solid phase peptide synthesis for …
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State-of-the-art REDOR and TEDOR methods for elucidation of protein structure and interactions
Protein structure determination is vital for elucidating their function, folding or misfolding pathways, and their interaction with other biomolecules, small molecules and membranes. In the field of neurodegenerative disorders like Parkinson’s Disease and Alzheimer’s Disease, amyloid fibrils that …
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Isoform Selective Regulation of Adenylyl Cyclase By Small Molecule Inhibitors and Gbetagamma Protein
<p>The nine membrane-bound isoforms of adenylyl cyclase (AC), via synthesis of the signaling molecule cyclic AMP (cAMP), are involved in many isoform specific physiological functions. All nine isoforms share a similar structural organization; thus, AC isoform differences in physiological function …