Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"Proteins and Peptides"”.
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Structure determination of proteins and peptides in solution: simulation, chirality and NMR studies
… by means of molecular dynamics, chirality and NMR studies. In the last decades, many algorithms were designed for the protein secondary structure assignment, which reveals the local protein shape adopted by segments of amino acids. In this regard, the use of local chirality for the protein …
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Ultrasonic Absorption in Solutions of Proteins and Peptides and in Suspensions of Liposomes
… apomyoglobin, (alpha)-lactalbumin, bacitracin, and the C and N-terminal CNBr cleavage fragments of myoglobin and equeous suspensions of large unilamellar lipid vesicles (LUV) of various compositions. Measurements were performed at temperatures between 20(DEGREES)C and 50(DEGREES)C in the …
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A study of the aggregating cationic antibacterial proteins and peptides in bovine seminal plasma
… microorganisms. Among them are well researched proteins like lysozyme and lactoferrin, systems like the myeloperoxidase- and lactoperoxidase-mediated system, and two complement systems. Also, a number of mammalian cationic proteins and peptides have been found to have antibacterial properties. …
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Automated data acquisition and analysis for high-resolution Fourier transform mass spectrometry of proteins and peptides
… progress made in automating the data acquisition and data processing of MS and MS/MS data from Fourier transform ion cyclotron resonance mass spectrometers. These instruments have made great strides in the past few years, moving from labor-intensive, largely manual systems to the current flagship …
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Study of proteins after recovery from bacterial infection
… The objective of this study was to compare the proteins and peptides present in the microglia of BCG-challenged mice one-week after treatment relative to control mice and gain insights through differential detection and enrichment analysis. Detection relied on tandem mass spectrometry …
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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins
<p>Peptides and proteins are imperative for the human body and play crucial roles in governing various bio-chemical processes. Recent advances in molecular biology and biochemistry helped in understanding the role of these endogenous macromolecules in different pathological and disease conditions. …
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The Nuclear Magnetic Resonance Study of Lipid Protein Interactions in Model Membrane Systems
… a useful probe of the state of acyl chain order and rate of motion in bilayer membranes. In order to determine the effect of membrane protein upon the state of lipid motion, a variety to deuterium labeled phosphatidylcholines have been synthesized and these have been reconstituted with several …
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Protein and Peptide Solubility - In Silico and In Vitro Approaches
… property to optimise in the development of peptides and proteins as therapeutic compounds. Biologics, which are drugs based on biological compounds such as proteins, inherently possess many beneficial properties such as low toxicity and high specificity. Often, however, they exhibit only …
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Proliposome Technology for Protein Delivery
… delivery of macromolecules, particularly proteins and peptides. However, limitations such as short transit time and loss of activity of some proteins and peptides in the respiratory tract need to be overcome. Consequently, the utility of controlled drug delivery systems such as liposomes …
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Molecular cloning, structural characterisation and functional study of bioactive peptides from amphibian skin secretion
Amphibians make a tight relationship between land and water as they have to protect themselves from various situations and survive by producing defensive skin chemicals, including alkaloids, proteins and peptides. In recent years, research on peptides from the skin secretion of frogs has attracted …
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Dynamics characterization for designing functional soft materials
… their function. In biological materials such as proteins and peptides, the edict that 'structure dictates function' has been supplanted in recent decades by recognition that features like intrinsic disorder, conformational distribution, and solvent dynamics often play a part which is equally …
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Generation and characterisation of biologically active milk-derived protein and peptide fractions
… been carried out on the health benefits of milk proteins and peptides. Biologically active peptides are defined as specific protein fragments which have a positive impact on the physiological functions of the body; such peptides are produced naturally in vivo, but can also be generated by …
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An integrated top-down and bottom-up proteomic platform to reveal potential salivary biomarkers of the rare disorders SAPHO syndrome, Wilson’s disease and Hereditary angioedema
Wilson’s disease, SAPHO syndrome and Hereditary angioedema are three rare disorders characterized by a wide spectrum of different clinical manifestations, which involve several organs and apparatus, making the diagnosis extremely difficult. In this study, the salivary proteome and peptidome of …
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Differential Proteomic Investigations Of Normal Appearing Gray Matter In Multiple Sclerosis And Control Post-Mortem Brain Tissue.
… of multiple sclerosis (MS). To more thoroughly and efficiently elucidate potential alterations in the expression of mitochondrial and related proteins, The mitochondrial proteome in motor and parietal cortex has been characterized using Surface-Enhanced Laser Desorption Ionization Time of Flight …
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Functional Protein Delivery Using Polymeric Nanoparticles: A Novel Therapeutic Approach to Alpha-Synuclein Aggregation and Parkinson's Disease
An efficient route for delivering specific proteins and peptides into neurons could greatly accelerate the development of therapies for various diseases, especially those involving intracellular defects such as Parkinson's disease (PD). Synthetic nanoparticles made from polybutylcyanoacrylate …
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Orthogonal Protein Synthesis by Ribosomes with an Integrated mRNA
… the mRNA into the amino acid sequence of proteins. Given the importance of proteins and peptides, many efforts have focused on engineering the ribosome to expand its functionality beyond its repertoire of only 20 naturally occurring proteinogenic amino acids. However, developing such …
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Surface functionalisation of encoded SU-8 microparticles and their uses in multiplexed suspension biological assays
… contain micrometre-sized diffractive elements and can encode millions of unique codes. In this thesis, the preparation and surface modification of different diffractive microparticles; the attachment of a range of biological molecules (e.g. proteins and peptides) onto the functionalised …
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Designing Amphiphilic Peptoids for Controlling the Formation of Nanostructured Biomimetic Materials
Biomacromolecules such as proteins and peptides achieve remarkable functionality through precise molecular sequences, enabling sophisticated folding and hierarchical assembly. However, their complexity and sensitivity in folding and assembly raise significant challenges for molecular design and …
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Profiling medulloblastoma and juvenile pilocytic astrocytoma brain tumours in a South African paediatric cohort
… one of the most challenging diseases to treat, and so outcomes are variable and often lacking. There are currently no reliable data of presentation of disease, the spectrum of tumours treated, how these are treated, and what the outcomes are for children in South Africa, and certainly no …
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The discovery of a novel peptide from the defensive skin secretion of Hylarana guentheri
… of bioactive compounds. To date, thousands of proteins and peptides with diverse biological activities have been isolated from amphibian skins. Antimicrobial peptides (AMPs) are one of the most essential groups of these molecules. AMPs are relatively small molecules, which have recently …
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