Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Protein-tyrosine kinase"”.
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Growth regulation of prostate cancer by the intracellular protein tyrosine kinase 6.
… of prostate cancer by the intracellular protein tyrosine kinase 6.
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Perturbation Modeling for Molecular Design of Protein Tyrosine Kinase Inhibitors using Unsupervised Machine Learning
… transformations of small molecules to SRC kinase inhibitors using a combination of a generative learning technique called Variational Auto-Encoders and Unsupervised Machine Learning techniques. This study focuses specifically using the methods above to transform molecules from various …
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Post-translationally Modified Glucocorticoid Receptors and Protein Tyrosine Kinase 6 Modulate Triple Negative Breast Cancer Phenotypes
… Growth Factor β1 (TGFβ1) and Mitogen Activated Protein Kinase (MAPK) signaling gene sets associated with TNBC cell survival and migration/invasion. Accordingly, pS134-GR was essential for TNBC cell anchorage-independent growth in soft-agar, migration, invasion, and tumorsphere formation, an in …
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Development of Machine Learning Models for Generation and Activity Prediction of the Protein Tyrosine Kinase Inhibitors
… approaches for generation and scoring of novel kinase inhibitor molecules. We utilized a binary Random Forest classification model to develop a Machine Learning based scoring function to evaluate the generated molecules on Kinase Inhibition Likelihood. By training the model on several chemical …
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B Cell Activation: The Regulation by T Cells and the Induction of the Protein Tyrosine Kinase SYK
… for membrane immunoglobulin-mediated tyrosine phosphorylation with the requirements for downstream signaling events. Our results demonstrate that receptor crosslinking is required for the accumulation of tyrosine phosphorylated proteins and for the induction of in vitro …
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Tyrphostin AG126 modulates Toll-like receptor (TLR) activation-induced functions in microglia by protein tyrosine kinase (PTK) -dependent and -independent mechanisms
Tyrphostine stellen eine Klasse synthetischer Protein-Tyrosin-Kinase (PTK)-Hemmer, die sich strukturell vom Tyrosin ableiten und dazu dienen, spezifisch Substratphosphorylierungen zu verhindern. Tyrphostin AG126 zeigte entzündungshemmende Eigenschaften in zahlreichen Tiermodellen von Erkrankungen. …
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DFer Protein-Tyrosine Kinase : its involvement in the Amyloid Precursor Protein (APP)-induced blistered wing phenotype and its functional characterization in Drosophila melanogaster
Das “Amyloid Precursor Protein” APP ist das Vorläuferprotein des A?-Peptides, welches als Bestandteil der amyloiden Plaques im Gehirn von Alzheimer Patienten auftritt. Obwohl die Entstehung von A? durch die proteolytische Spaltung von APP sehr gut untersucht ist, ist die physiologische Funktion von …
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Regulation of the myogenic response and stretch-induced calcium signaling in the vascular wall: Novel insights into the role of microRNAs and protein tyrosine kinase 2
… thesis investigates novel roles of microRNAs and protein tyrosine kinase 2 in pressure/stretch-induced signaling mechanisms in the vascular wall. Using two different knockout mouse models, we uncovered a novel role of microRNAs in the pressure-induced myogenic response. We demonstrated that global …
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Clinical and Biological Patterns in Soft Tissue Sarcoma
… RET, KIT and FLT4 within the receptor protein tyrosine kinase pathway, are significantly up-regulated. In summary, these studies show that high referral rates of STSs to a sarcoma center are possible to achieve, that small STSs with necrosis and vascular invasion had high risk of …
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STRESS GRANULES MODULATE SYK TO CAUSE MICROGLIAL DYSFUNCTION IN ALZHEIMER’S DISEASE
… that defects in the functions of the protein-tyrosine kinase SYK, which is important both for macrophage activation and phagocytosis, might underlie much of this pathology. Recent evidence from our lab indicates that SYK can associate with stress granules, ribonucleoprotein particles …
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<i>Ixodes Scapularis</i> SRC Kinase Is Required for Rickettsial Pathogen Survival in Ticks
… in order to increase its survival in ticks. Src kinase, a non-receptor protein-tyrosine kinase, is a major player in cell signaling. Src kinase has an impact on the spread and survival of <em>A</em>. <em>phagocytophilum</em> in ticks. Studies on Src kinase in <em>I. scapularis</em> show that …
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Role of Syk in the regulation of cytoskeleton and stress granules in breast cancer
<p>The Syk protein-tyrosine kinase, a well-characterized modulator of immune recognition receptor signaling, also plays important, but poorly characterized, roles in tumor progression, acting as an inhibitor of cellular motility and metastasis in highly invasive cancer cells. Multiharmonic atomic …
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Biochemical and genetic analysis of the adaptor protein SH3P7 : insights from a newly generated knockout mouse
… is a widely expressed actin-binding adaptor protein identified as a substrate for protein tyrosine kinase (PTK) after BCR activation. In addition to two protein-binding modules specific for filamentous actin, SH3P7 also contains an SH3 domain. The biochemical studies presented here, show that …
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Ocorrência de eventos adversos relacionados a inibidores de tirosina quinase de primeira e segunda geração : revisão de literatura
… fusion gene is transcribed and translated into protein BCR - ABL1. The tyrosine kinase inhibitors (TKIs) act by blocking the binding of ATP at the ABL1 kinase domain inhibi ts phosphorylation and resulting in cell death. Imatinib was the first inhibitor of protein tyrosine kinase BCR / ABL1 to …
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The effects of mechanical forces on lymphocyte adhesion and migration
… regulation. Lastly, we examined the effects of protein kinase C and protein tyrosine kinase on lymphocyte adhesion and migration.
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Methods to Improve Virtual Screening of Potential Drug Leads for Specific Pharmacodynamic and Toxicological Properties
… data sets such as lymphocyte-specific protein tyrosine kinase inhibitors (Lck) and phosphoinositide 3-kinase inhibitors (PI3K). Further investigated were toxicological data sets such as eye and skin irritation, compounds that produce reactive metabolites, and hepatotoxicity. To the best …
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
… collagens bind the collagen-specific receptor tyrosine kinase discoidin domain receptor 1 (DDR1), implicated in regulating cell proliferation, migration, adhesion, ECM remodeling, and response to growth factors. Additionally, collagen has been shown to promote chemoresistance in pancreatic …
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The cloning and characterization of the TIK kinase.
Protein phosphorylation is a mechanism of modulating protein activity which plays a central role in a wide variety of cellular functions. The ready reversibility of the phosphotransfer reaction makes it well-suited for rapid cellular responses, such as the responses to signals from extracellular …
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Phospho-regulation and metastatic potential of Murine Double Minute 2
… (Mdm2) is a highly modified and multi-faceted protein that is overexpressed in numerous human malignancies. It engages in many cellular activities and is essential for development since deletion of mdm2 is lethal in early stages of embryonic development. The most studied function of Mdm2 is as …
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Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress
… mechansomes contain an adhesion-associated protein and a nucleocytoplasmic shuttling transcription factor. “GO” mechanosomes functions to promote the anabolic response of bone to mechanical loading, while “STOP” mechanosomes function to suppress the anabolic response of bone to mechanical …
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