Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Protein-protein interactions (PPIs)"”.
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The NTF2L Domain Is a Date Hub That Interacts with SLiMs to Regulate Assembly of Stress Granules
… within cells. Biomolecules condense through interactions. When the sum and duration of collective interactions reach the percolation threshold, a system-spanning inter- action network is achieved, resulting in phase separation to create a low-viscosity liquid, i.e., biomolecular condensate. …
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Directed Evolution of Macrocyclic Peptides For Inhibition of Autophagy
… macrocyclic peptides targeting the autophagy protein LC3. The resulting peptides bound LC3A and LC3B—two essential components of the autophagosome maturation machinery—with mid-nanomolar affinities and disrupted protein-protein interactions (PPIs) between LC3 and its binding partners in vitro. …
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Discovery of Molecules that Modulate Protein-Protein Interactions in the Context of Human Proliferating Cell Nuclear Antigen-Associated Processes of DNA Replication and Damage Repair
Integral to cell viability is the homotrimeric protein complex Proliferating Cell Nuclear Antigen (PCNA) that encircles chromatin-bound DNA and functionally acts as a DNA clamp that provides topological sites for recruitment of proteins necessary for DNA replication and damage repair. PCNA has …
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Modeling and designing Bc1-2 family protein interactions using high-throughput interaction data
Protein-protein interactions (PPIs) play a major role in cellular function, mediating signal processing and regulating enzymatic activity. Understanding how proteins interact is essential for predicting new binding partners and engineering new functions. Mutational analysis is one way to study the …
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WDR5 Network Analysis Using Ensemble Approaches
<p>Understanding the properties of protein-protein interactions (PPIs) is necessary to deconvolute the processes inside living organisms. As such, research in this regard has significant implications for gaining insight into cancers and other diseases. Once understood, drugs can be designed to …
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Computational design of orthogonal antiparallel homodimeric coiled coils
Living cells integrate a vast array of protein-protein interactions (PPIs) to govern cellular functions. For instance, PPIs are critical to biosynthesis, nanostructural assembly, and in processing environmental stimuli through cell-signaling pathways. As fields such as synthetic biology and protein …
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New reporters of protein trafficking and protein-protein interactions in live cells
… to harness the exquisite specificity of natural protein and RNA enzymes to develop improved methods to study protein localization and protein-protein interactions in live cells. We first attempted to detect endogenous protein-protein interactions (PPIs) in live cells by means of a ribozyme …
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Pathosystems Biology: Computational Prediction and Analysis of Host-Pathogen Protein Interaction Networks
… of systems biology is the elucidation of the protein-protein interactions (PPIs) that control important biological processes within a cell and between organisms. In particular, at the cellular and molecular level, interactions between a pathogen and its host play a vital role in initiating …
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Structure-function Analysis of the STRIPAK Complex
… has proven to be a powerful tool to identify protein-protein interactions (PPIs) involving kinases and phosphatases. Using AP-MS we discovered a novel-signaling complex, which we termed STRIPAK (for STRiatin Interacting Phosphatase and Kinase). The STRIPAK complex contains a protein …
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Analysis of the biophysical and in silico exploration of the interaction between small ribonucleoprotein G and the RING finger domain of retinoblastoma binding protein 6 for the identification of protein anti-cancer compounds
… and develop cancer treatment methods using protein-protein interactions (PPIs) have become promising targets for therapeutic discovery. Suggestive evidence has proposed putative interactions between Small nuclear ribonucleoprotein polypeptide G (SNRPG) (also referred to as SmG in this study) …
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Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
The inhibition of protein-protein interactions (PPIs) presents a major challenge to drug discovery. The properties of consensus-designed tetratricopeptide repeat proteins (CTPRs) make them very amenable to be rationally-designed into potential new PPI inhibitors. This study sets out to investigate …
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The development of functionalised stapled peptides as chemical tools to modulate biological processes in platelets and as novel antimicrobial therapeutics targeting Pseudomonas aeruginosa
Peptides are useful modulators of protein-protein interactions (PPIs) and cellular membranes, both of which are traditionally challenging to target using small molecules. Often therapeutic peptides suffer from issues including poor proteolytic stability. Two-component peptide stapling can improve …
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Strain-promoted Stapled Peptides for Inhibiting Protein-protein Interactions
Protein-protein interactions (PPIs) are responsible for the regulation of a variety of important functions within living organisms. Compounds which can selectively modulate aberrant PPIs are novel therapeutic candidates for treating human diseases. Whilst PPIs have traditionally been considered as …
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A screen for novel interactions within the vertebrate centriole
… of some human diseases. The identification of protein-protein interactions (PPIs) can progress our understanding of the assembly process. In this thesis, I follow two approaches towards this objective. First, I conduct a large-scale combinatorial screen of 3025 binary test pairs amongst a …
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Predicting the Interactions of Viral and Human Proteins
… strategies requires a firm understanding of the interactions taken place between the proteins of the virus and human proteins. The current computational models for predicting these interactions consider only single viruses for which extensive prior knowledge is available. The two prediction …
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Protein-Protein Interactions with Serotonin G Protein Coupled Receptors: Novel Targets for Neurotherapeutics Drug Discovery
G protein coupled receptors (GPCRs) are involved in many physiological processes and are important therapeutic targets for a variety of human health disorders. In fact, approximately 30% of current FDA-approved medications target GPCRs and that number is likely to continue to rise with current …
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Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
… domains occur in approximately one third of all proteins, yet these domains are less well understood compared with their globular counterparts. TR proteins act as molecular scaffolds that facilitate protein-protein interactions (PPIs) in diverse biological contexts. In disease pathologies such as …
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The development of stapled peptides as chemical tools to investigate activin A signalling and as antibacterial agents targeting MsbA-mediated efflux
… are recognised for their ability to disrupt protein-protein interactions (PPIs), which have traditionally been considered ‘undruggable’ with small molecules. However, due to issues such as a susceptibility to degradation by proteases, the use of peptide therapeutics in the clinic has been …
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Structure-based algorithms for protein-protein interaction prediction
Protein-protein interactions (PPIs) play a central role in all biological processes. Akin to the complete sequencing of genomes, complete descriptions of interactomes is a fundamental step towards a deeper understanding of biological processes, and has a vast potential to impact systems biology, …
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Investigation towards the role of LmxOSM3.1 phosphorylation and the identification of its interaction partners using an improved method of proximity labelling
… LF4, whereby down regulation of either protein promotesciliary elongation. As both LmxOSM3.1 and LmxMPK13 are implicated in flagellar regulation, it is hypothesised that LmxOSM3.1 functions as a substrate of LmxMPK13 and together they coordinate flagellum length.;In 2C-mTID, a …
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