Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Protein-protein interaction (PPI)"”.
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Elucidating the role of Mitoferrin (Mfrn), Iron Regulatory Proteins (IRP1 and IRP2) and Hephaestin (Heph) in Iron Metabolism by tagSNP and Protein-Protein Interaction (PPI) analysis
… establish the role of different iron metabolic proteins, Mitoferrin (Mfrn), IRPs and Heph in iron homeostasis. Analysis of 18 tagSNPs in the Mfrn gene was carried out in an Asian-Caucasian population to establish any correlation between the Mfrn tagSNPs, haemoglobin levels and birth weight in …
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Network-based approach for post genome-wide association study analysis in admixed populations
… and the locus-specific ancestry into the human protein-protein interaction (PPI) network to identify significant sub-networks or pathways associated with the trait of interest. This network-based method applies centrality measures within linkage disequilibrium (LD) on the network to search for …
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Modular architecture in biological networks
… Using computational techniques and pre-existing protein-protein interaction (PPI) data, we have developed general tools to find and validate modular structure. We have applied these approaches to the PPI networks of yeast, fly, worm, and human.
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Protein Function Prediction Using Graph Convolutional Network
This project advances protein function prediction by integrating protein language models (PLMs) and graph convolutional networks (GCNs), addressing the limitations of traditional methods that rely heavily on sequence similarity. The proposed model leverages diverse protein features, including …
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Structurally Motivated Deep Learning for Genome Scale Protein Interaction Prediction
Protein-protein interaction (PPI) networks have proven to be a valuable tool in systems biology to facilitate the discovery and understanding of protein function. However, experimental PPI data remains sparse in most model organisms and even more so in other species. Existing methods for …
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Biophysical investigations of the interaction between substrate binding domain of Hsp40 and the RING finger domain of Retinoblastoma Binding Protein 6
… side effects of current chemotherapy treatments. Protein-protein interactions have recently come onto the scene as potential targets for novel treatment and management options for the disease. Through a yeast-two hybrid study, the RING finger domain of the Retinoblastoma binding protein 6 (RBBP6) …
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TARGETING THE NRF2/KEAP1 INTERACTION
The Nrf2/Keap1 protein-protein interaction (PPI) regulates activity of the Nrf2 antioxidant and anti-inflammatory pathway. The transcription factor Nrf2 has been found to be a key mediator in the resolution of inflammation and the progression of chronic diseases. Most known inducers of the Nrf2 …
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Prediction and Investigation of Novel Proteins in DNA Double Stranded Break Repair
… of DNA. The process of NHEJ involves three main protein complexes: Yku70/Yku80 initiates and stabilizes the DNA ends, Mre11/Rad50/Xrs2 brings broken ends to close proximity and Dnl4/Lif1/Nej1 ligates the DNA ends. Protein-protein interaction (PPI) has been utilized in functional genomics studies …
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Annotating Human Interactome to Predict Pathways and Systematically Analyzing Network Rewiring in Cancer across Multiple Tissues
Human protein-protein interaction (PPI) networks are essential in regulating most cellular processes and their disruption can cause complex diseases such as cancer. Currently, hundreds of thousands of binary PPIs comprise human interactome, but they lack annotations about tissue- or …
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A study of bioprocess designs for development of the myogenic secretome as a source of bioactive extracellular vesicles
… upstream process for myogenic secreted EVs and proteins was optimised over 7-days. Analytics involved quantification of secretome yield and extracellular vesicle (EV) characterisation. Internalisation of myogenic EVs by human chondrocytes was investigated to examine bioactivity. Effects of EVs …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
… of Nav channels is a source of less conserved protein-protein interaction (PPI) interfaces that represent a novel opportunity for designing isoform-specific chemical leads targeting Nav channels. The macromolecular complex of Nav channels is regulated by a number of accessory proteins. Very few …
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Design and synthesis of molecular tools for the ubiquitin proteasome system
… proteasome system (UPS), in particular the interaction between a mutant form of ubiquitin, Ubb+1, and the E2-conjugating enzyme E2-25K, has been identified as playing a possible pathophysiological role in the early and late stage progression of AD. The E2-25K/Ubb+1 protein-protein …
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Development of stapled peptide targeted covalent inhibitors and synthesis of novel ADC payloads for applications in cancer therapy
… covalent inhibitors (SPTCIs) of p53–MDM2 protein–protein interaction (PPI). Herein, the development and synthesis of three novel electrophilic staples and four stapled peptides are described. The stapled peptides bear moieties to covalently target a surface-exposed lysine residue on MDM2, …
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Discovery of New Protein-DNA and Protein-Protein Interactions Associated With Wood Development in Populus trichocarpa
… factors (TFs) are DNA-binding regulatory proteins capable of either activation or repression by binding to a specific region of DNA, normally located in the 5-prime upstream promoter region of the gene. In the first section of this work, six DNA promoters from wood formation-related genes …
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Large Scale Cross-Linking Mass Spectrometry as the Missing Link in the Systems Biology Toolbox
The function of a protein is mediated by its ability to form precise three-dimensional structures or specific protein-protein interaction (PPI) interfaces. However, it has been challenging to study these aspects of the proteome at scale, in sufficient detail, and in a generalisable way. …
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Ontology alignment in the presence of a domain ontology : finding protein homology
… algorithms are forced to align without human interaction. Bioinformatics, for example, has seen the influx of large ontologies, such as signal pathway sets with thousands of elements or protein-protein interaction (PPI) databases with hundreds of thousands of elements. This drives the need for …
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Integrative analysis of heterogeneous genomic datasets to discover genetic etiology of autism spectrum disorders
… similarity based on either sequence, phenotype, protein-protein interaction (PPI) network, or functional annotation. Another increasingly accepted view is that human diseases result from perturbations of molecular networks, and genes causing the same or similar diseases tend to be close to one …
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Single-cell Analysis of Structural and Immune Cell Interactions in Periodontitis
… of cell-type–specific responses and coordinated interactions within the periodontal microenvironment. OBJECTIVE: This study aimed to compare the transcriptional landscapes of structural and immune cell populations in periodontitis versus healthy gingival tissues using single-cell analysis, with a …
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Approaches Towards the Inhibition of Anti-Apoptotic Proteins
Anti-apoptotic proteins play a fundamental role in cell survival. Under physiological conditions, such proteins trigger apoptosis in defective or damaged cells only; under pathological conditions, however, they can be dysregulated allowing the cells to survive despite being harmful. Considering the …
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Algorithms for the analysis of protein interaction networks
… of systems biology: the understanding of protein interactions. Such understanding is valuable: interactions between proteins are fundamental to many cellular processes. Over the last decade, high-throughput experimental techniques have allowed us to collect a large amount of …
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