Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 274 for “"Protein-protein interaction"”.
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Protein-Protein Interaction Network Alignment
Proteins are some of the building blocks of organisms. They usually perform their functions by interacting with each other and forming protein complexes. A protein -protein interaction network is a graph that consists of proteins as vertices and their interactions as edges. Protein-protein …
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Human protein-protein interaction prediction
Protein-protein interactions are essential for the survival of all living cells, allowing for processes such as cell signalling, metabolism and cell division to occur. Yet in humans there are only >38k annotated interactions of an interactome estimated to range between 150k to 600k interactions and …
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Targeting the p53/MDM2 protein-protein interaction
The p53/MDM2 protein-protein interaction is the most widely characterised proteinprotein interaction to date. As of 2014, there are over 20 compounds that have been shown to the p53-MDM2 protein-protein interaction, however many compounds have not progressed into clinical trials due to their high …
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Towards a comprehensive human protein-protein interaction network
Obtaining a reliable interaction data set describing the human interactome is a milestone yet to be reached. The past few years has seen tremendous progress in elucidating the yeast interactome. Experimental approaches for obtaining large-scale protein interaction data coupled with powerful …
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The genetic landscape of protein-protein interaction specificity
Protein-protein interaction specificity is often encoded at the primary sequence level, and by just a few interfacial residues. Collectively, these residues have both positive and negative roles, promoting a desired, cognate interaction and preventing non-cognate interactions, respectively. …
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Structure-based algorithms for protein-protein interaction prediction
Protein-protein interactions (PPIs) play a central role in all biological processes. Akin to the complete sequencing of genomes, complete descriptions of interactomes is a fundamental step towards a deeper understanding of biological processes, and has a vast potential to impact systems biology, …
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Expanding the Spiroligomers Toolbox as Protein-Protein Interaction Inhibitors
… application of spiroligomers as inhibitors of protein-protein interactions. After the discovery of an acyl-transfer coupling reaction by Dr. Zachary Brown, a previous graduate student of Schafmeister group, the synthesis of highly functionalized spiroligomers that mimic the helical domain of …
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Investigation of protein-protein interaction using atomic force microscopy
… approaches to measuring the kinetics of protein dissociation have the advantage that measurements can be performed in native environments, such as living cells, where concentrations of target molecules may be quite low. In addition, single molecule approaches allow for the measurement of …
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Design and Synthesis of Small-Molecule Protein-Protein Interaction Antagonists
Protein-protein interactions play a crucial role in a wide range of biological processes. Research on the design and synthesis of small molecules to modulate these proteinprotein interactions can lead to new targets and drugs to modulate their function. In Chapter one, we discuss the design and …
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The Protein-protein Interaction Map of the Treponema pallidum Flagellar Apparatus
… stellt den ersten umfassenden Versuch dar, die Protein-Protein-Interaktionen (PPIs) eines bakteriellen Flagellenapparats genomweit zu erfassen. Wir haben dafür Treponema pallidum ausgewählt, also Spirochäten, die auch die Syphilis auslösen. T. pallidum hat ein kleines Genom mit nur 1,041 Genen, …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
… of Nav channels is a source of less conserved protein-protein interaction (PPI) interfaces that represent a novel opportunity for designing isoform-specific chemical leads targeting Nav channels. The macromolecular complex of Nav channels is regulated by a number of accessory proteins. Very few …
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Protein-protein interaction between multi-functional protein CAD and protein phosphastase 1 (PP1)
… with activation of CAD, a multifunctional protein that catalyzes the first three steps in pyrimidine biosynthesis. The cell cycle dependent regulation of pyrimidine biosynthesis is a consequence of sequential phosphorylation of CAD Thr-456 and Ser-1406 by the MAP kinase and PKA cascades, …
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Design of protein-protein interaction specificity using computational methods and experimental library screening
Computational design of protein-protein interaction specificity is a powerful tool to examine and expand our understanding about how protein sequence determines interaction specificity. It also has many applications in basic bioscience and biotechnology. One of the major challenges for design is …
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Design and synthesis of probes for detection of protein-protein interaction and RNA localization
… for detecting the formation of cyan fluorescent protein and NF-kappaB p50 dimers was assessed. A series of benzophenone-based probes were synthesized and tested for photocrosslinking activity to investigate the efficiency of photocrosslinking in these systems. Three series of small molecule …
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Engineered human cytochrome c : investigation of superoxide and protein-protein interaction and application in bioelectronic systems
… with the superoxide radical and the selected proteins sulfite oxidase from human and fungi bilirubin oxidase. All three interaction partners are studied here for the first time with human cyt c and with mutant forms of cyt c. A further aim is the incorporation of the different cyt c forms in …
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Inference frameworks in computational biology: from protein-protein interaction networks using machine learning to carbon footprint estimation.
Protein-protein interactions (PPIs) are essential to understanding biological pathways and their roles in development and disease. Computational tools have been successful at predicting PPIs in silico, but the lack of consistent and reliable frameworks for this task has led to network models that …
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Discovery and Effects of Pharmacological Inhibition of The E3 Ligase Skp2 By Small Molecule Protein-Protein Interaction Disruptors
<p>Skp2 (S-phase kinase-associated protein 2), one component of the SCF E3 ubiquitin ligase complex, directly interacts with Skp1 and indirectly associates with Cullin1 and Rbx1 to bridge the E2 conjugating enzyme with its protein substrate to execute its E3 ligase activity. Skp2 is an Fbox protein …
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Protein-Protein Interaction and Structure-Function Studies of XcpR, a Protein Involved in Extracellular Protein Secretion of Pseudomonas Aeruginosa
… and toxins. The extracellular secretion of these proteins requires at least eleven xcp gene products (XcpP-Z) and the bifunctional peptidase/methylase, PilD. Although a number of macromolecular translocation mechanisms have been found in a wide range of bacterial species that involve xcp-related …
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