Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 455 for “"Protein-protein Interactions"”.
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Theoretical Studies of Protein-Protein Interactions
Proteins are known to play major roles in most processes taking place inside living cells. Understanding their functions and mechanisms of their action is one of the most important problems in the fields of biochemistry and biophysics. In this work we study a kinase called Extracellular Signal …
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Eukaryotic Transcriptional Activation Mechanism: Protein-Protein Interactions
… demonstrated to have physical and functional interactions with TBP and/or TFIIB. Given the central role of TBP in transcriptional regulation, I also identified distinct TBP domains (or residues) important for different regulatory interactions including those with acidic activators, TFIIB, Dr1 …
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Computational prediction of human protein-protein interactions
… While identifying individual genes and their protein products is crucial, understanding how these entities exist within the context of other molecules within the cell provides valuable insight into their functional significance. In particular, mapping the intricate web of interactions between …
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Evolution and engineering of protein-protein interactions
Protein-protein interactions are crucial elements in most biological processes. The gain and loss of interactions during evolution have important phenotypic consequences that are subject to selection. Therefore, in a crowded cellular environment, proteins must evolve mechanisms to maintain the …
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Systems Biology of Host-Pathogen Protein-Protein Interactions
… parasite that co-opts host cellular proteins, often through protein-protein interactions (PPIs), to ensure its replication. Therefore, this thesis aims to integrate high-throughput proteomic approaches with computational modelling to systematically characterize SARS-CoV-2-human …
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Small molecule inhibition of immunoregulatory protein-protein interactions
Selective molecular recognition between proteins is a fundamental event in biological processes that governs cellular growth, function, survival, and differentiation. The immune system, for example, is a complex network of cellular processes regulated by protein-protein interactions (PPIs) between …
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Study of correlation analysis for protein-protein interactions
Protein-protein interactions take place when two or more proteins bind together, usually to carry out some biological functions. Many biological processes are formed by interaction networks that are consisted of more than one protein-protein interaction. To understand the proteins’ function …
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Discovery of macrocyclic inhibitors of challenging protein-protein interactions
… This library was screened against the MDM2/p53 protein-protein interaction from which a sub-micromolar inhibitor was identified. In my third project, I again applied these tools to prepare a macrocycle library which was targeted for binding to the IL-23 receptor at the binding site of IL-23. …
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Structural enzymology of soluble methane monooxygenase protein-protein interactions.
… feat of catalytic prowess requires all three protein components of sMMO for efficient multiple turnover catalysis: the hydroxylase (sMMOH), the reductase (MMOR), and the regulatory protein (MMOB). The structural mechanism of how these sMMO components interact to regulate the formation and …
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Protein-Protein Interactions and Muscle cell Signaling Via Syntrophin
… dystrophin is associated with a complex of proteins and glycoproteins, known as the dystrophin glycoprotein complex. The DGC constituents are dystrophin, a-dys troglycan, b-dystroglycan, syntrophin, a-sarcoglycan, b-sarcoglycan, g-sarcoglycan, d-sarcoglycan, and sarcospan. Not al l of these …
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Protein kinases: Structure modeling, inhibition, and protein-protein interactions
<p>Human protein kinases belong to a large and diverse enzyme family that contains more than 500 members. Deregulation of protein kinases is associated with many disorders, and this is why protein kinases are attractive targets for drug discovery. Due to the high conservation of the ATP binding …
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Machine learning for the prediction of protein-protein interactions
The prediction of protein-protein interactions (PPI) has recently emerged as an important problem in the fields of bioinformatics and systems biology, due to the fact that most essential cellular processes are mediated by these kinds of interactions. In this thesis we focussed in the prediction of …
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O-GlcNAc-Mediated Protein-Protein Interactions in Cell Signaling
<p>Protein modification by O-linked β-N-acetylglucosamine (O-GlcNAc) is an essential signaling mechanism that affects diverse processes such as cell cycle, metabolism, and death. Aberrant signaling has been implicated in numerous human diseases including cancer and neurodegeneration. However, major …
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Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
The inhibition of protein-protein interactions (PPIs) presents a major challenge to drug discovery. The properties of consensus-designed tetratricopeptide repeat proteins (CTPRs) make them very amenable to be rationally-designed into potential new PPI inhibitors. This study sets out to investigate …
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Strain-promoted Stapled Peptides for Inhibiting Protein-protein Interactions
Protein-protein interactions (PPIs) are responsible for the regulation of a variety of important functions within living organisms. Compounds which can selectively modulate aberrant PPIs are novel therapeutic candidates for treating human diseases. Whilst PPIs have traditionally been considered as …
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Protein-protein interactions of human somatic angiotensin-converting enzyme
In this study, novel disulphide bridges were engineered into the linker region of ACE [Angiotensin-converting enzyme] in an attempt to limit inter-domain movement, thereby producing a candidate for crystallisation and to determine the effect of these bridges on inter-domain movement.
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Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
… Of the four canonical coronavirus structural proteins, the envelope (E) protein remains the least well-characterised, despite its critical functions in viral assembly and release, as well as its role as a major contributor to viral pathogenesis. Its contribution to viral pathogenesis has been …
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Deep learning and coevolution reveal proteome-wide protein-protein interactions
The total set of potential protein-protein interactions (PPI) within an organism's proteome guides a plethora of potential biological processes at an organism’s disposal. Understanding these PPIs is critical to our understanding of biological systems, however identifying interactions with high …
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