Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Protein-membrane interactions"”.
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Dynamics of protein-membrane interactions in drug metabolism and cancer
The cell membrane forms a critical barrier between the environment and the inner biochemical machinery of every life form on earth. Without the membrane, vital metabolic processes almost certainly could not occur. Many of these processes also require proteins present at or even embedded within the …
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Atomic-level characterization of protein-lipid interactions using molecular dynamics simulations
Peripheral membrane proteins are structurally diverse proteins that are involved in fundamental cellular processes. Their activity of these proteins is frequently modulated through their interaction with cellular membranes, and as a result techniques to study the interfacial interaction between …
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A Simulation Approach to the Study of Bacterial Secretion Proteins
… of the structure and dynamics of cellular protein complexes is essential for understanding their functionally relevant interactions. In Gram-negative bacteria, the complex machinery associated with the type II secretion system (T2SS) polymerises inner membrane pseudopilin proteins into thin …
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Polyphosphate and tissue factor/factor VIIA as initiators of coagulation
Protein-membrane interactions are a critical component of the coagulation cascade. For many coagulation factors, these interactions are mediated via γ-carboxyglutamate rich regions, or GLA domains, in a Ca2+-dependent manner. Nearly all studies of GLA domain-containing coagulation factors, and …
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Membrane and membrane protein dynamics studied with time-resolved infrared spectroscopy
Proteins are the machinery of the cell, performing functions essential for life. Proteins do not operate in isolation, however. Their function is intimately coupled to their environment; changes in this environment modulate the behavior of the protein. One of the most striking examples of …
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Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
… is dedicated to investigating how specific protein-ligand interactions in the active site affect selectivity and affinity of inhibitors; how ATP-competitive inhibitors affect membrane binding of PI3Kα; how known membrane binding inhibitors of coagulation factor V and VIII C2 domains affect …
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Molecular and genetic studies on a SipD/IpaD-related virulence spike protein from immune-suppressive particles of a Drosophila parasitoid
… The EVs possess spikes and contain hundreds of proteins, some of which enable wasp eggs to escape encapsulation by changing the morphology and function of hemocytes, or killing them. Previous studies have identified an abundant surface/spike protein (SSp40) from <em>Leptopilina heterotoma</em> …
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Structural investigations of membrane-interacting proteins using nuclear magnetic resonance spectroscopy and other biophysical techniques
Structural information of protein is vital for understanding its function as well as its interactions with membrane and other proteins. Aberrant protein expression or disruption in protein-protein/protein-membrane interactions lead to disease formation. Membrane-interacting proteins play critical …
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Interactions of Proteins with Membranes: Insights from Molecular Dynamics Simulations
Membrane proteins play a crucial role in numerous biological processes, including signal transduction, molecular transport, and cell recognition. Due to their involve- ment in fundamental physiological functions and their relevance as pharmacological targets, understanding their structure and …