Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Protein-lipid interactions"”.
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Protein -Lipid Interactions in Soluble Nanoscale Lipid Bilayers
… the binding of steptavidin to biotinylated lipids and annexin to phosphoserine lipids in Nanodiscs."
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Atomic-level characterization of protein-lipid interactions using molecular dynamics simulations
Peripheral membrane proteins are structurally diverse proteins that are involved in fundamental cellular processes. Their activity of these proteins is frequently modulated through their interaction with cellular membranes, and as a result techniques to study the interfacial interaction between …
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Protein-lipid interactions in molecular pathways of Parkinson’s and Alzheimer’s diseases
… are characterised by the accumulation of proteinaceous pathogenic inclusions in the central nervous system. The key proteins involved in the pathogenesis of AD and PD are amyloid β 1–42 (Aβ42) and α-synuclein (αS), which cause the toxicity in AD and PD through aberrant interactions with …
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Advances in understanding protein-lipid interactions through biophysical and bioelectronic approaches
Intrinsically disordered proteins (IDPs) are those that to do not possess a well-defined three dimensional structure. As a result, they show great flexibility when it comes to adopting a suitable conformation based on the target of interest. However, due to the nature of the free energy landscape …
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Computational investigation of protein-lipid interactions and lipid modulation of membrane proteins
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Protein-lipid interactions in raft-exhibiting membranes probed by combined AFM and FCS
… entity, far from being an inert assembly of protein and lipids which separates cells from the surrounding environment. A multitude of biological processes, ranging from active transport of ions into and out of the cell, to the immune response, are regulated at the level of the plasma …
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Probing human disease through protein-ligand and protein-lipid interactions via molecular simulation
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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A Deuterium Nuclear Magnetic Resonance Study of Protein Dynamics and Protein-Lipid Interactions in Model and Biological Membranes (Nmr)
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1984.
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Lipid-protein interactions of immunoreceptor signaling subunit cytoplasmic domains
Protein-lipid interactions are emerging as key components of cellular processes such as protein and membrane trafficking and cell-cell signaling. Many proteins bind lipid reversibly, including cytoplasmic proteins involved in signal transduction, such as Ras and Src. Membrane binding is vital for …
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Multiplex analysis of protein-lipid and protein-membrane protein interactions utilizing silicon photonic microring resonators
… for many biological functions. When soluble proteins interact with the cell surface, the crowded and complex environment can act as a signaling mechanism and influence blinding and activity. Parsing out the components of the membrane that influence binding is a time consuming process. There …
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Characterization of a Novel Signaling Motif in the CD3 ε Subunit of the T Cell Receptor
… interacted with the serine/threonine kinase, G protein-coupled receptor kinase 2 (GRK2). Interactions between the BRS and GRK2 contribute to the ability of the TCR to cross talk with G protein-coupled receptors, such as CXCR4. The BRS was also capable of mediating interactions with certain …
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Cell-free platform for the functional characterization of intracellular ion transporters
In biotechnology, the study of membrane proteins is of high interest due to their unique physical properties used as invaluable tools for the development of new therapeutics. However, honing down on the structural and functional properties of membrane proteins is no easy feat, owing to challenges …
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Analysis of factors that affect pseudotyping in retroviruses
… pseudotype with various envelope glycoproteins; however, the molecular mechanism of glycoprotein acquisition process is not completely understood even with their native Env proteins. Understanding this mechanism would aid development of a safe and efficient retroviral gene therapy …
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Recruitment and function of ORP1L on the Coxiella burnetii parasitophorous vacuole
… of the role of cholesterol-binding host protein ORP1L (Oxysterol binding protein-Related Protein 1, Long) during infection. ORP1L is a multi-functional cholesterol-binding protein involved in late endosome/lysosome (LEL) trafficking, formation of membrane contact sites between LEL and the …
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Magic angle spinning NMR applied to membrane protein 2D crystals : the structure and function of VDAC
Membrane proteins mediate critical functions in biological systems and are important drug targets for a number of diseases. Determining the three-dimensional structure and function of membrane proteins under physologically relevant conditions is a long sought-after goal in structural biology. In …
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Structure, Function and Dynamics of G-Protein coupled Receptors
Understanding the function of membrane proteins is crucial to elucidate the molecular mechanisms by which transmembrane signaling based physiological processes,i. e., the interactions of extracellular ligands with membrane-bound receptors, are regulated. In this work, synthetic transmembrane …
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
Lipids and proteins are two major components of cells, which are crucial for structural integrity and maintenance of cellular homeostasis by integrating various extracellular and intracellular cues. Lipids are involved in the regulation of cellular functions and can interact with proteins and …
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The Assembly of Pathogenic Signaling Circuits by a Family of Bacterial Secreted Effector Proteins
Bacterial type III secreted effector proteins facilitate Gram-negative bacterial replication, dissemination, and immune evasion in the infected host organism. While much attention has been focused on the cell inhibitory mechanisms of these virulence factors, there is emerging evidence that …
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Simulating atomic-level interactions in the coagulation cascade
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Structural and Functional Basis for the Autoregulation of the Adaptor Protein TOM1
Target of Myb 1 (TOM1) is an endosomal adaptor protein that plays a role in cargo membrane trafficking for degradation by serving as an alternative endosomal sorting complex required for transport component. TOM1 has also been shown to serve as a novel phosphatidylinositol 5-phosphate (PtdIns5P) …
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