Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Protein-Tyrosin-Kinasen"”.
-
Charakterisierung der Proteinkinase DYRK1A : Substrat- und Autophosphorylierung
… encodes an evolutionary highly conserved protein kinase. Due to different animal models and its genomic localisation on human chromosome 21, is it considered a candidate gene in mental retardation of the Down-syndrome. Little was known about the cellular function of DYRK1A, but comparison …
-
Studien zum endosomalen Transport und der Signaltransduktion des Nervenwachstumsfaktors NGF unter physiologischen und pathophysiologischen Bedingungen
… by the accumula-tion of ubiquitinated proteins within the affected neurons. Part one of this thesis aimed to elucidade whether the proteasome influences the function of the NGF receptor TrkA. Proteasomal inhibition led to an alteration of the endosomal trans-port of TrkA, switching from …
-
Charakterisierung der Auswirkungen einer pathogenen Mutation im Neurotrophinrezeptorgen trkA im Zellkulturmodell
… effects were accompanied by an impairment of protein stability of the mutated receptor and changes in the viability of transiently transfected cells. Hence a model is discussed in which the mutation R780P leads to the sorting of the receptor into recycling endosomes which allows a minimum of …