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Showing 1 to 20 of 38 for “"Protein-Serine-Threonine Kinases"”.
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Nucleocytoplasmic Localization of MAPKs
Mitogen-activated protein kinases (MAPKs) comprise a family of protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events. MAPKs are regulated by phosphorylation cascades, which are usually initiated by external stimuli including a variety …
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Esi47, a stress-inducible protein kinase gene from Lophopyrum elongatum is involved in plant hormone signaling
… Lophopyrum elongatum . The Esi47 gene encodes a protein kinase with highest amino acid sequence similarity to the NAK group of protein serine/threonine kinases. Esi47 and the NAK group protein kinases have a central catalytic domain flanked by short amino and carboxyl terminal non-catalytic …
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Identification of Substrates and Pathways Regulated by WNK1
WNK (With No lysine (K)), a serine/threonine protein kinase, is a unique molecule not belonging to any other canonical protein kinase family including mitogen-activated protein (MAP) kinases. The name of the WNK protein kinase family reflects the fact that a catalytic lysine lies in a position …
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Analysis of Aurora B Regulation and Signaling
Aurora B is a serine/threonine kinase that functions in a complex with two other chromosomal passenger proteins called INCENP and Survivin. Its function is implicated in a variety of processes related to mitosis, such as chromosome condensation, regulation of arm cohesion, spindle assembly, …
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A Lateral Root Defect in the wag1-1/wag2-1 Double Mutant of Arabidopsis
… roots has been well defined. WAG1 and WAG2 are protein-serine/threonine kinases from Arabidopsis that are closely related to PINOID and suppress root waving. The wag1;wag2 double mutants exhibit a strong root waving phenotype on vertical hard agar plates only seen in wild-type roots when the …
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Regulation of Cell Migration by WNK1
… focused on the regulation of cell motility by a serine/threonine protein kinase, WNK1 (With No lysine (K)1), so named because of the absence of a conserved lysine within the catalytic domain. Although WNK1 has been most thoroughly characterized for its role in controlling ion flux in the kidney, …
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Regulation of Human Telomerase Alternative Splicing
… reporter for a selected 528 RNA-binding proteins/splicing factors siRNA screen. Our initial validation focused on 45 factors with enzymatic activity and resulted in CDC-Like Kinase 1 (CLK-1) as a potential hTERT splicing modulator. Knock-down of CLK-1 altered hTERT splicing, resulting in …
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With No Lysine 1 (WNK1): A Potential Regulator of The Lysosomal Degradation Pathway
With no Lysine (K) 1 (WNK1) is an atypical serine/threonine protein kinase that has its catalytic lysine positioned in a unique location. This kinase, along with another member of the WNK family, WNK4, has been genetically linked to pseudohypoaldosteronism type II (PHAII), which is characterized by …
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With No Lysine (WNK) Family Proteins and Their Interaction with Downstream Kinases
With no lysine (WNK) kinases are a family of protein kinases characterized by unusual kinase domain architecture. These large proteins, divergent outside of a kinase core and protein-protein interaction motifs, have been associated with pseudohypoaldosteronism 2, a form of Mendelian-inherited …
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Identification of Substrates and Pathways Regulated by PAS Kinase
PAS kinase, a serine/threonine protein kinase, is unique in that it comprises the only mammalian protein kinase regulated by a PAS domain. The interest of the McKnight laboratory in understanding the regulation and biological role of PAS kinase stems from knowledge that PAS domains typically …
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Interaction Mapping of the Atypical Protein Kinase WNK3
The story of the protein kinase "with no lysine 3" (WNK3) represents a unique chapter in the larger story of protein kinases, the so-called 'molecular switches' of the cell that serve the vital function of phosphorylating myriad proteins. In doing so, these enzymes furnish the cell with one of the …
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Functional Genomics Based Interrogation of Cell-Fate Determination Pathways
The Hedgehog (Hh) and Wnt signal transduction pathways are master regulators of embryogenesis and tissue renewal and represent anticancer therapeutic targets. Using genome-wide RNA interference screening in murine cultured cells, I established previously unknown associations between these signaling …
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Investigating the Biological Functions of the Protein Kinase WNK1 in the Regulation of Cytoskeletal Structures and Membrane Trafficking
The file named "TU-DISSERTATION-2013.pdf" is the primary dissertation file. Twelve (12) supplemental videos are also provided (in Audio Video Interleaved format).
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Structural and Functional Analysis of HIV-1 Nef Activation of PAK-2
Nef is an accessory protein encoded by HIV-1 that activates the host cellular p21 activated protein kinase 2 (PAK-2). Previous work has characterized the structural plasticity of Nef with regard to PAK-2 activation. Residues 89 and 191 were identified to be components of an effector domain required …
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Characterizing New Molecules and Mechanisms of Semaphorin/Plexin/MICAL Signaling
… cues, members of the Semaphorin family of proteins, induces actin cytoskeletal changes. Interestingly, Semaphorins have been found to inhibit the movement of cells and their membranous processes but the molecules linking them to these specific behaviors have remained poorly understood. …
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Structural Analysis of Domain Swapping in the Protein Kinase: Crystal Structure of Human Ste20 OSR1 Kinase Domain
Ste20p (Sterile 20 protein) is a yeast MAP4K involved in the pheromoneresponsive MAPK cascade of the mating pathway. Recent studies reveal that its homologs in mammals, Drosophila melanogaster, Caenorhabditis elegans and other organisms constitute a large emerging group of protein kinases including …
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Understanding Potassium Homeostasis Using Human and Mouse Genetic Models
… Studies in PHA2 have revealed that WNK kinases regulate renal sodium transporters and potassium channels. WNK1 enhances the endocytosis of renal outer medullary potassium (ROMK) channel through an intersectin-dependent mechanism, but the upstream regulator is still unknown. Here, I …
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Studies of the Hippo Signaling Pathway
… cassette consisting of four tumor suppressor proteins, the Ste20-like kinase Hpo, the WW domain-containing protein Salvador (Sav), the NDR family kinase Warts (Wts) and the Mob family protein Mats. The kinase activities of Hpo and Wts are facilitated by their regulatory proteins Sav and Mats, …
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Structural Analysis of STE20-Related Proline-Alanine-Rich Kinase (SPAK)
… by the WNK (With No lysine (K)) family of protein kinases. Overexpression of WNK1 has been associated to a hereditary form of hypertension. The link between WNK-SPAK-cotransporters provides one of the functional pathways for WNK to regulate intracellular and extracellular salt and water …
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WNK Family Kinases and the Regulation of Ion Flux
… of the with no K (lysine) or WNK family of serine/threonine protein kinases have an unusual arrangement of their catalytic lysines. WNK1 and WNK4 have been genetically linked to a rare type of hypertension. Studies demonstrate that these kinases regulate the activity of a diverse group of …
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