Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Protein-Motifs"”.
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Analysis of SMAUG1 protein motifs and interacting partners - linking regulation of phase separation to human disease
RNA-binding proteins (RBPs) are central regulators of gene expression, influencing RNA processing, localisation, translation, and decay. A growing body of evidence shows that many RBPs exert their functions through the formation of dynamic, membrane-less organelles (MLOs) via liquid–liquid phase …
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Design and development of a site specific protein patterning technique for use in a microfluidic antibody separation device
… surfaces presenting multiple micron scale protein motifs, for integration within a microfluidic channel device, is described in this thesis. <br/><br/>Initial research focussed on conjugating protein motifs on silicon <100> substrates in micron and submicron scale patterns. A method …
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Genetic and biochemical analysis of a conserved DEAD-box helicase motif
DEAD-box proteins are non-processive helicases that use ATP to power unwinding of short RNA duplexes in essential steps of RNA metabolism. Despite acting on a diverse range of RNA substrates, DEAD-box proteins share a helicase core defined by 13 highly conserved amino acid motifs. Here we use S. …
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A study on human IFIT3 modulation of IFIT1 protein stability
Interferon-induced proteins with tetratricopeptide repeats (IFITs) are expressed in both interferon-dependent and interferon-independent manners in cells after pathogen-associated molecular pattern recognition by the pathogen recognition receptors. Four IFITs (IFIT1, IFIT2, IFIT3 and IFIT5) have …
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Regulation of filopodia dynamics is critical for proper synapse formation
… by the recruitment of proper postsynaptic proteins, however the precise function of filopodia remains controversial. Thus the goal of this study was to investigate the dynamics of dendritic filopodia and determine their role in the development of synaptic contacts. We initially define and …
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Nuclear proteomics and transcription factor profiling in Chlamydomonas reinhardtii
… approaches were followed. In order to indentify protein transcriptional regulators we optimized a method for isolation of nuclei and performed nuclear proteome analysis using shotgun proteomics. This analysis permitted us to improve the genome annotation previously published and to discover …
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The genetic and biochemical analysis of Drosophila Wwox protein function.
… to ionising radiation (IR), a number of Wwox proteins specifically deleted or mutated at positions consisting of conserved functional protein motifs, or regions that are highly conserved among WWOX / Wwox homologs. The Wwox variants were tested for their ability to modify the IR sensitivity …
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Role of WD domain-containing proteins in cell cycle progression
… proteome, WD domain is one of the most abundant protein motifs. The structure of WD domain allows it to interact with diverse protein partners and proteins containing WD domain have been shown to function in various cellular processes. In this thesis, I describe how two WD domain-containing …
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A structural classification of protein-protein interactions for detection of convergently evolved motifs and for prediction of protein binding sites on sequence level
… era of Bioinformatics is the prediction of protein-protein interactions, and ultimately the prediction of protein functions. The problem is intrinsically harder, when only amino acid sequences are available, but a solution is more universally applicable. So far, the problem of uncovering …
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Female sterility and carpel development in plants
… factors, hormone related functions, transporter proteins, and kinase proteins. We also identified chromatin related proteins which presumably work to maintain genome integrity and accuracy. Of the loci identified to be differentially expressed between males and females, a majority was found to be …
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The Major Histocompatibility Complex in Rabbits
… immunity is to produce cell surface glycoproteins that bind intracellularly or extracellularly derived peptides and display these epitopes for T-cell recognition, thereby facilitating the elimination of pathogens or the establishment of self-tolerance. The MHC is traditionally classified …