Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"Protein tyrosine kinases"”.
-
Investigations into the chemistry of protein tyrosine phosphatase redox regulation
… the reversible phosphorylation of specific protein tyrosine residues. This reversible phosphorylation serves as a biochemical "rheostat" that alters a protein's functional properties and leads to propagation of the signal. The phosphorylation status of these tyrosine residues, thus …
-
A study of keratinocyte differentiation and adhesion in vitro
… of cells expressing differentiation-specific proteins. I showed that this was not caused by calcium-induced cell-cycle arrest, nor was it a consequence of stratification. However, the expression of differentiation-specific proteins was preceded by the formation of cadherin-mediated cell-cell …
-
B Cell Activation: The Regulation by T Cells and the Induction of the Protein Tyrosine Kinase SYK
… for membrane immunoglobulin-mediated tyrosine phosphorylation with the requirements for downstream signaling events. Our results demonstrate that receptor crosslinking is required for the accumulation of tyrosine phosphorylated proteins and for the induction of in vitro …
-
The analysis of B cell antigen receptor (BCR) mutants deficient in antigen-independent signaling reveals novel BCR-associated proteins
… pervanadate (PV). Analysis of substrate <br>tyrosine phosphorylation after PV-treatment of different B cell lines expressing BCR mutants <br>revealed drastic differences in phosphorylation of two signaling proteins namely the SH2- <br>domain-containing inositolpolyphosphate 5’-phosphatase …
-
Role of the Abelson Tyrosine Kinases in Regulating Macrophage Functions in Immunity and Cancer
<p>The Abl family of protein tyrosine kinases regulates diverse cellular processes by coordinating cytoskeletal rearrangements. Recent data indicate that pharmacological inhibition of Abl kinases reduces inflammation in preclinical models and in the clinic. While a previous role for Abl kinases in …
-
Specificity of SH2 domains and protein tyrosine phosphatases
… signals are transmitted within cells involves protein phosphorylation. For example, signal transmission from many extracellular signaling molecules is initiated by receptors that are themselves protein tyrosine kinases (PTKs) or have an associated PTK activity. SH2 domains and protein tyrosine …
-
The Role of Il-8-Mediated Src Family Kinase Activation In Tumor-Tumor and Tumor-Stromal Interactions In Metastasis of Prostate Cancer
… better therapies for PCa. Aberrant activation of protein tyrosine kinases, including Src Family Kinases (SFKs) contribute to metastasis through numerous functions, one of which leads to increased expression of cytokines, such as IL-8. However, the relationship between Src activity and IL-8 …
-
Function, expression and evolution of the *Src family kinases in Caenorhabditis elegans
… the prototype of a family of membrane-associated protein tyrosine kinases involved in cell signaling pathways that control cell growth, development, and differentiation. Activation of Src by mutation or overexpression has been implicated in a range of cancers, particularly breast and colon cancer. …
-
Protein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem Cell Self-Renewal
… are regulated by signaling through protein tyrosine kinases (PTK) such as c-kit, Flt-3 and Tie2. PTKs work in concert with receptor protein tyrosine phosphatases (PTPs) to maintain cellular equilibrium. The functions of PTPs in counterbalancing PTK signaling in HSCs however remain …
-
Cloning and characterization of novel kinases from embryonic cells.
Protein tyrosine kinases (PYKs) play key regulatory roles in the control of cell growth and differentiation. Attempts to identify novel PYKs through expression cloning strategies have led to the identification of a novel family of protein kinases, referred to as dual specificity kinases (DSKs). In …
-
Molecular determinants regulating Bruton’s tyrosine kinase activity and their mechanism: a combined computational and experimental approach
<p>Understanding allostery in proteins is critical in understanding their unique regulatory mechanisms and this knowledge can be exploited to develop highly specific, targeted therapies. In this dissertation, we have investigated the unique sequence elements that regulate the activity of a protein …
-
Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… antibodies, and GN. Lyn is a Src-family tyrosine kinase that, in general, inhibits B cell and myeloid cell activity. Loss of Lyn results in cellular hyperactivity associated with autoantibody production. Bruton’s tyrosine kinase (Btk), which is critical to B cell receptor (BCR) signaling, …
-
Modeling Brk/PTK6 expression in the mammary epithelium.
Protein tyrosine kinases (PTKs) regulate cellular proliferation and differentiation during development and homeostasis of normal tissues. Additionally, PTKs are frequently overexpressed in cancers. As such, they have become promising targets for new therapies. Breast tumor kinase (Brk/PTK6) is a …
-
Deciphering AXL-Driven Molecular Mechanisms of EMT
Pages xviii-xix are misnumbered as pages xix-xx.
-
Validation of AXL as a Therapeutic Target in Pancreatic Cancer
… a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family, has been identified as a critical factor that drives metastasis and immune suppression in many cancer types. Here we demonstrate that AXL-deficient PDA bearing mice have longer median survival, smaller tumors, fewer …
-
Identification of a Low Molecular Weight Protein Tyrosine Phosphatase and Its Potential Physiological Substrates in Synechocystis sp. PCC 6803
The predicted protein product of open reading frame slr0328 from Synechocystis sp. PCC 6803, SynPTP, possesses significant amino acid sequence similarity with known low molecular weight protein tyrosine phosphatases (PTPs). To determine the gross functional properties of this hypothetical protein, …
-
Molecular Players in Lupus: Leads from Proteomic Screens
… We have discovered that soluble Axl receptor tyrosine kinase, the Wnt/β-catenin pathway-related factors, and rare fibrinogen alpha chain variant A-α-E are elevated in the serum of patients with SLE. Here I explore these factors and their contributions to disease. I find that Axl tyrosine …
-
Biochemical and physiological changes in bovine sperm during extended incubation under aerobic and anaerobic conditions
… glycolysable substrate is available. Changes in protein tyrosine phosphorylation, viability and motility were studied as a function of extended storage of bovine sperm in vitro at ambient temperature (18-20°C). Over a period of 8 days of storage at ambient temperature there was a time-dependent …
-
Pathogenic and Protective Potential of B Cell Dysregulation in Systemic Lupus Erythematosus
… by which autoantibodies accumulate in SLE. Protein arrays can be used to identify autoantibodies and autoantigens that are targeted in SLE patients. Using this approach, we identified Stress Induced Phosphoprotein 1 (STIP1) as an autoantigen in a subset of SLE patients. Those patients with …
-
Characterizing PIAS1 Function During Embryogenesis and Lung Cancer Progression
… cell lung cancers (NSCLC). The SUMO E3 ligase protein inhibitor of activated STAT-1 (PIAS1) is one the few known SUMO conjugating enzymes known to date. PIAS1 was first discovered as a negative regulator of signal transducer and activator of transcription 1 (STAT-1), from which its name is …
Page 1 of 2