Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Protein tyrosine kinase 2 (Pyk2)"”.
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
… collagens bind the collagen-specific receptor tyrosine kinase discoidin domain receptor 1 (DDR1), implicated in regulating cell proliferation, migration, adhesion, ECM remodeling, and response to growth factors. Additionally, collagen has been shown to promote chemoresistance in pancreatic …
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Molecular signaling programs underlying neutrophil polarity and chemotaxis
… remain poorly defined. We have identified Pyk2, a FAK (focal adhesion kinase) family non-receptor tyrosine kinase, as a beta2-integrin-dependent regulator of rear contraction in migrating neutrophil cells. We show that Pyk2 is specifically activated by beta2-integrin and that Pyk2 mediates …