Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Protein therapeutics"”.
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Development and biophysical characterization of a hyaluronic acid – vitamin E conjugate as a subcutaneous delivery platform
The inherent properties of protein therapeutics (e.g. high molecular weight, charged, conformationally dependent) has historically limited their administration to parenteral routes which presents new challenges to their controlled delivery. Hydrogel and nanoparticle drug delivery systems can …
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The Path to an Orally Administered Protein Therapeutic for the Treatment of Diabetes Mellitus
<p>Protein therapeutics like insulin and glucagon-like peptide-1 analogues are currently used as injectable medications for the treatment of diabetes mellitus. An orally administered protein therapeutic is predicted to increase patient adherence to medication and bring a patient closer to metabolic …
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Analyzing the interactions of thermoresponsive coacervate-forming biodegradable polyester encapsulation on model protein structure and activity
<p>Protein therapeutics hold high efficacy in treatment for various diseases including cancer and diabetes. However, the treatment cost is generally higher than other therapeutics mainly due to <em>in vivo</em> protein degradation. This drawback creates demand for more efficient delivery methods to …
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Development of polymeric nanoparticulate formulation encapsulating protein molecules following hydrophobic ion pairing complexation
… to enable sustained delivery of antibody therapeutics by nanoparticulate based dosage forms. However, development of sustained release nanoparticulate based dosage form for protein therapeutics represents a real challenge to scientists. These protein molecules are prone to denaturation …
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Affinity-based Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering
… In this thesis, a strategy for delivering protein therapeutics in a localized and sustained fashion is presented within the context of these regenerative medicine challenges. An affinity-based system was developed whereby transient interactions between complementary binding partners were …
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Mammalian Cell Line Development Platform for Recombinant Protein Production: Expanding the Protein Expression Toolbox for Research and Drug Discovery Applications
<p>Recombinant proteins have revolutionized the biomedical industry, providing therapeutics for life-threatening diseases and protein reagents for research applications. BioMarin Pharmaceutical Inc. develops recombinant protein therapeutics to treat rare diseases including lysosomal storage …
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Developing scalable and modular technologies for continuous biopharmaceutical production
… the geographically biased nature of therapeutic protein production today can limit access to biologic drugs in developing areas of the world. These same logistical hurdles can also hamper the efficient distribution of life-saving protein therapeutics following crises in developed nations. …
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A novel in vivo protein refolding technique
<p>Proteins perform their functions in their native folded states and misfolding of proteins may cause severe diseases, including Alzheimer's disease, Parkinson's disease, prion disease and diabetes. Understanding protein folding is important for us to engineer proteins to treat these diseases. For …
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Organisation of Glutamatergic Inputs to Central amygdala
… subunit. Interestingly, exogenous application of protein therapeutic is able to alleviate pain induced mechanical hypersensitivity by restoring the GluD1 levels. This report will open a new arena of using protein therapeutics in modulating pain phenotypes and serve as a potential alternative to …
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Biomolecular function and failure across length scales
Nature has evolved proteins to form the fundamental machinery of life through controlled assembly. Such protein assembly can span five orders of magnitude in length scale, from subnanometer intramolecular arrangements to the formation of micron- sized compartments. However, our understanding of …
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A directed evolution approach to engineering recombinant protein production in S. cerevisiae
The continued success of protein therapeutics has put a strain on industry's ability to meet the large demand. Creating a more productive expression host for the manufacture of these proteins is a potential solution. Although heterologous proteins are frequently made in organisms as disparate as E. …
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Uniform biodegradable microparticle systems for protein delivery
Therapeutic protein drugs are receiving increasing attention in pharmaceutical industry due to the fast development of biotechnology and genomics. Because of their low oral and transdermal bioavailabilities, fragility and short half-lives in vivo, novel and effective alternatives to deliver protein …
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Cavitation in Vial Drop Subjected to Mechanical Shock
… work from the Randolph lab demonstrated that protein aggregates can form when a vial of therapeutic solution is dropped onto a hard surface. The process by which this occurs is most likely shock induced cavitation. During this process, hot spots can be created with temperatures and pressures …
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A novel intracellular protein delivery system - Magnesium phosphate nanoparticles with cationic lipid coating for catalase intracellular delivery
<p>Protein therapeutics have great potential in treating human disease, especially for those caused by alternations in the functions of intracellular proteins. However, clinical use of protein by intracellular delivery has been hampered by the instability due to proteins' physicochemical …
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Development of polymer and lipid materials for enhanced delivery of nucleic acids and proteins
… intracellular delivery of macromolecular therapeutics such as nucleic acids and proteins could potentially catalyze the clinical translation of many gene and protein-based therapies. However, progress has been hindered by a lack of safe and effective materials and by insufficient insight …
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Targeted drug delivery within the eye
… of the work determines the ability to deliver protein therapeutics into the cornea using coated microneedles to suppress corneal neovascularization in a rabbit model. The data show that highly targeted delivery of the anti-vascular endothelial growth factor protein therapeutic gave a better …
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Studies and applications of protein prenylation using isoprenoid analogues and site-directed mutagenesis
The site-specific enzymatic modification of proteins offers a powerful tool both for the development of new research techniques and for the development of more effective therapeutics. Protein farnesyltransferase (PFTase) is a promising tool in the field of site-specific protein modification due to …
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PEGylated Tissue Repair Peptide TP508 Derivatives as Second Generation Drugs for Radiomitigation and Other Systemic Applications
… for modifying therapeutic peptides and small proteins to improve these characteristics is through covalent attachment to polyethylene glycol moieties, a process known as PEGylation. Because TP508 is currently being evaluated as a nuclear countermeasure drug for radiomitigation, this project …
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Studies investigating the preparation of solid core drug delivery systems for oral delivery of y-globulin via supercritical fluid processing technology
The rising interest in protein therapeutics has led to the growing research in the development of novel carrier systems particularly for oral delivery. However, several physicochemical and biological barriers pose as a challenge for the use of biomolecules as oral drug therapies. Solid core drug …
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Micro-bioreactor design for Chinese hamster ovary cells
… an important cell line for producing recombinant protein therapeutics. In order to translate a micro-bioreactor originally designed by our group for bacteria to CHO cells, there would need to be significant modifications in the design of the micro-bioreactor due to the extreme sensitivity of CHO …
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