Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Protein synthesis inhibition"”.
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Protein Synthesis Inhibitors Impair Memory by Disrupting Release of Neurotransmitters Important for Memory Modulation
"The theory that de novo protein synthesis is necessary for memory consolidation is widely accepted, yet supported by evidence based primarily on results using protein synthesis inhibitors. Injection of a protein synthesis inhibitor near the time of training often spares memory of the training …
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An assessment of reconsolidation blockade to disrupt memories relevant to psychiatric disorders
… with NMDA receptor antagonists or protein synthesis inhibition can lead to a decrease in subsequent memory expression. This may offer a potential tool for the treatment of psychiatric disorders characterised by maladaptive memories, including drug addiction and post-traumatic …
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Investigation into the mechanisms responsible for muscle atrophy in cancer cachexia
… inducing tumours are known to produce a glycoprotein called proteolysis inducing factor (PIF), which induces skeletal muscle atrophy via increased protein degradation and decreased protein synthesis. The objective of this study was to investigate the signalling pathway by which PIF reduces …
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Stenodactilina e lanceolina: due nuove potenti “ribosome-inactivating proteins” bicatenarie. Purificazione, caratterizzazione chimico-fisica e studio dei meccanismi citotossici
… Adenia stenodactyla, respectively. They are glycoproteins with Mw of 61,243 (lanceolin) and 63,131 daltons (stenodactylin), consisting of an enzymatic A chain linked to a larger B chain with lectin properties, with N-terminal amino acid sequences similar to that of volkensin, the toxic lectin from …
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Biophysical responses of lymphocytes to environmental stress
… proxy for deformability. Finally, we find that protein synthesis inhibition, cell cycle arrest, protein kinase inhibition, and cytoskeletal disruption result in unexpected relationships between deformability, density, and volume. Taken together, our results suggest that measuring multiple …
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Investigating the Therapeutic Potential of L-asparaginase in Myeloid Leukemia
… treatment, in addition to the well-established protein synthesis inhibition mechanism. The findings from this study indicate that L-asparaginase elicits classical responses of amino acid deprivation in myeloid cells at both transcriptional and translational levels. In addition, pathway analysis …
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Method development for the characterization of intrinsic and extant kinetic parameters in microalgal cultures
Algal bioprocesses for wastewater treatment have the potential to simultaneously recover nitrogen and phosphorous while also producing feedstocks for bioenergy and bioproducts. In order to develop reliable treatment processes for water resource recovery facilities, however, it is critical that we …
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Genetic control of death in Chinese Hamster Ovary cultures
… time. This inability translates into lower final protein titers and higher protein production and recovery costs. This thesis was undertaken to better understand the processes of death in CHO cells and to find ways to extend the viability of CHO cultures. A majority of CHO cells in culture were …