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Showing 1 to 9 of 9 for “"Protein structure modeling"”.
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New Methods to Improve Protein Structure Modeling
<p>Proteins are considered the central compound necessary for life, as they play a crucial role in governing several life processes by performing the most essential biological and chemical functions in every living cell. Understanding protein structures and functions will lead to a significant …
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Improving Structural Features Prediction in Protein Structure Modeling
<p>Proteins play a vital role in the biological activities of all living species. In nature, a protein folds into a specific and energetically favorable three-dimensional structure which is critical to its biological function. Hence, there has been a great effort by researchers in both …
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De Novo Protein Structure Modeling and Energy Function Design
<p>The two major challenges in protein structure prediction problems are (1) the lack of an accurate energy function and (2) the lack of an efficient search algorithm. A protein energy function accurately describing the interaction between residues is able to supervise the optimization of a protein …
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De Novo Protein Structure Modeling from Cryoem Data Through a Dynamic Programming Algorithm in the Secondary Structure Topology Graph
<p>Proteins are the molecules carry out the vital functions and make more than the half of dry weight in every cell. Protein in nature folds into a unique and energetically favorable 3-Dimensional (3-D) structure which is critical and unique to its biological function. In contrast to other methods …
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Machine Learning and Optimization Algorithms for Intra- and Intermolecular Interaction Prediction
… intermolecular interactions, specifically intra- protein residue-residue interactions and the interaction sites in between proteins and other macromolecules, are critical for understanding numerous biological processes. The existing methods fall short in estimating the quality of intra-protein …
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Protein Structure Analysis and Prediction
The protein structure prediction problem consists of three separate subproblems: modeling the protein structure, modeling the protein energetics, and the problem of searching for low-energy structures in high-dimensional space in the presence of many local minima. This study presents a new approach …
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An Investigation Into Splicing Variation and Expression Patterns of Insulin-Like Peptide 4 (ILP4) Within the Drosophila Genus
… in an extra glutamic acid residue in the final protein structure. Initial analysis suggests that this variation may not significantly impact ILP4 functionality, but additional studies, such as protein structure modeling and function analysis, are necessary. Further identified is significant …
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Using structure to explore the sequence alignment space of remote homologs
The success of protein structure modeling by homology requires an accurate sequence alignment between the query sequence and its structural template. However, sequence alignment methods based on dynamic programming (DP) are typically unable to generate accurate alignments for remote sequence …
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Novel Electron Transfer Systems in Hyperthermophilic Methanogenic and Anaerobic Methanotrophic Archaea: F420-dependent Nitrite Reductase and [Fe-S] Cluster Assembling Thioredoxin
… (Trx) homolog with a new function. These proteins are involved in redox reactions, and the research presented here deals with the biochemistry of an Fsr and the Trx homolog. M. jannaschii Fsr (MjFsr) performs sulfite (SO32-) detoxification, converting SO32- encountered in its environment …