Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Protein secondary structure"”.
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Protein secondary structure mimetics : design, synthesis and evaluation
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Analysis of protein secondary structure via the discrete wavelet transform
<p>This project develops a secondary structure prediction approach that uses the discrete wavelet transform. In order to use the wavelet technique, we convert the primary amino acid sequence of the protein to a numerical signal using the hydrophobic tendencies associated with the amino acids. The …
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A multi-level nearest-neighbour algorithm for predicting protein secondary structure
A thesis on machine learning and prediction of protein secondary structure. We develop a variation of the nearest-neighbour algorithm that adopts a multi-level strategy together with a variable window size. The algorithm is applied to the problem of predicting the secondary structure of a protein …
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Fast learning optimized prediction methodology for protein secondary structure prediction, relative solvent accessibility prediction and phosphorylation prediction
… the number of sequences and the number of structures. There has been an exponential growth in the number of available protein sequences and a slower growth in the number of structures. There is therefore an urgent need to develop computed structures and identify the functions of these …
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Toward a Database of Geometric Interrelationships of Protein Secondary Structure Elements for De Novo Protein Design, Prediction and Analysis
… methods of analyzing, simulating, and modeling proteins are essential towards understanding protein structure and its interactions. Computational methods are easier as not all protein structures can be determined experimentally due to the inherent difficultly of working with some proteins. In …
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Language like behavior in protein secondary structure and analysis of mitochondrial genomes and transposable elements in Antarctic notothenioid fishes
… the Menzerath Altman Law (MA law) to examine the secondary structure of transcribed proteins. This law, derived within the field of linguistics, states that “the longer the system, the smaller its parts,” presenting an energy-balance principle in which system-level growth is compensated for by the …
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The Impact Of Nitrogen Fertilization On The Physico-Chemical, Functional, Amino Acid Profile, Protein Secondary Structure, And Bread Properties Of Intermediate Wheatgrass.
… and improved carbon sequestration. It has higher protein, dietary fiber, and ash. It is one of several perennial crops available for potential food use and the first commercially viable perennial grain in the United States. Lack of adoption of perennial grains for food use is essentially …
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Structure determination of proteins and peptides in solution: simulation, chirality and NMR studies
The study of protein fold is a central problem in life science, leading in the last years to several attempts for improving our knowledge of the protein structures. In this thesis this challenging problem is tackled by means of molecular dynamics, chirality and NMR studies. In the last decades, …
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Protein structure prediction and conformational transitions
<p>There is a critical need for protein structure and function prediction. Accurate protein secondary structure prediction is essential for many bioinformatics applications, including protein tertiary structure prediction. We developed an algorithm (Fragment Data Mining, FDM) for protein secondary …
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Foaming Novatein thermoplastic protein
… been a strong driver for bioplastic development. Proteins are naturally occurring biopolymers which can be denatured and plasticised to produce thermoplastic materials. Novatein Thermoplastic Protein (NTP) is a patented blend of blood meal (a highly aggregated protein) and processing additives …
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Graphene Microelectrode Arrays to Combine Electrophysiology with Fluorescence Imaging of Amyloid Proteins
… Both diseases are linked to the misfolding of proteins from their native conformational state into $\beta$-sheeted amyloid fibrils. In AD the implicated proteins are amyloid-$\beta$ and tau, and for PD the implicated protein is $\alpha$-synuclein (aSyn). The motivation for this work is to …
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Studies of biofluid analysis using 2D-IR spectroscopy
… to provide a quantitative analysis of the protein content of blood serum. The foremost challenge is obtaining protein measurements in physiologically relevant solvents as the most informative infrared peak relating to protein studies, the amide I band, overlaps with the bending mode of H2O, …
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Dynamics and Electrostatics of Membrane Proteins using Polarizable Molecular Dynamics Simulations
Membrane proteins are critical to many biological processes, including molecular transport, signal transduction, and cellular interactions. Through the use of molecular dynamics (MD) simulations, we are able to model this environment at an atomistic scale. However, traditionally used nonpolarizable …
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Neural Networks in Bioprocessing and Chemical Engineering
… networks and provides an overview of their structures, strengths, and limitations, together with a survey of their potential and commercial applications (Chapter 1). In addition to covering both the fundamental and practical aspects of neural computing (Chapter 2), this dissertation …
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Improving Impact Properties of Novatein through Polymer Blending and Reactive Extrusion
Novatein is a brittle thermoplastic made from protein and requires impact strength modification before it can be used in a wider variety of applications, such as in the agricultural, horticultural and meat processing industries. Polymer blending is often used for improving material properties cost …
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Evolution of protein structure, function, and dynamics in biological systems
… vary with different levels of granularity of the structure of biological systems. Different levels of organization and their parts often use similar strategies to achieve different goals. For example, at the organismal level cellular and viral proteomes leverage disorder to achieve advanced …
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Step-growth hydrogels crosslinked through grafted polypeptides enable nano- to macroscale synthetic extracellular matrix design
… chemical signaling, and 2) more closely mimic protein secondary structure found in the native extracellular matrix. A specific grafted N-carboxyanhydride polypeptide, poly(y-propargyl-L-glutamate) (PPLG), forms the foundation of this thesis. PPLG is an especially useful polymer for exploring …
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Self-assembly of globular protein-polymer diblock copolymers
Self-assembly of protein-polymer block copolymers provides a simple bottom-up approach towards protein nanopatteming for the fabrication of more effective and efficient bioelectronic and biocatalytic devices. Changes in shape and surface chemistry between proteinpolymer conjugates and classical …
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Structural Investigations of Nematode Anhydrobiotic and Rab11-FIP Proteins by Far-UV Circular Dichroism and Mid-IR Fourier Transform Infra-Red Spectroscopy
Analysis of the secondary structures of the standard proteins myoglobin, hemoglobin, lysozyme and a-chymotrypsin by CD spectroscopy resulted in excellent agreement of estimated fractional composition with that observed by x-ray crystallography. CD spectroscopy was found to be very accurate for …
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Development of an artificial silk protein on the basis of a lacewing egg stalk protein
… The mechanical properties mainly derive from the protein secondary structure and its higher order arrangement in silk fibres. Spider silk, for example, is known for its tensile properties surpassing nylon, Kevlar®, silkworm silk, and high-tensile steel.2-5 Beyond their mechanical properties, some …
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