Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Protein particles"”.
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Stable submicron protein particles : formation, properties, and pulmonary applications
… (TFF) processes were utilized to produce 300 nm protein particles with surface areas on the order of 31 - 73 m²/g and 100% protein activities. Despite a cooling rate of ~10²-10³ K/s in SFL and TFF, the particle sizes and surface areas were similar to those observed in the widely reported process, …
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Investigating late stage biopharmaceutical product loss using novel analytical and process technology
The biopharmaceutical industry uses recombinant protein technologies to provide novel therapeutics to patients around the world. These technologies have presented exciting opportunities for breakthrough medical treatments while creating a host of challenges in the discovery, development and …
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Hydrocyclone fractionation of chickpea flour and measurement of physical and functional properties of flour and starch and protein fractions
… contains a high amount of starch and valuable protein. Many grain legumes (pulses) can be processed by pin milling and air classification with high separation efficiency. However, chickpea exhibits low separation efficiency because it has a relatively high fat content compared to other pulses. …
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Cavitation in Pharmaceutical Manufacturing and Shipping
<p>Therapeutic proteins are used to successfully treat hemophilia, Crohn's Disease, diabetes, and cancer. Recent product recalls have occurred because of sub-visible particle formation resulting from the inherent instability of proteins. It has been suggested that particle formation is associated …
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The effect of degradation on the efficacy and utility of the biopharmaceutical enzyme Erwinia Chrysanthemi L-Asparaginase
… problem in the development of biopharmaceutical proteins is the lack of understanding around the implications of aggregation, or of their gradual, often partial degradation. Often aggregated or degraded protein variants comprise a small percentage of a biopharmaceutical protein sample, so it is …
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Aggregation of IgG mAb Biotherapeutics: Sources, Methods of Characterization, and Biological Implications
One of the predominant concerns with protein therapeutics is their tendency to aggregate at various stages of protein production, purification, filling, transportation, and administration. This occurrence has biological significance; while there is no definite, general cause and effect relationship …
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Regulating transcript fate through RNA elements in the 3' untranslated region
Regulation of protein production is the most vital part of molecular biology. Typically the focus of such endeavors has been on the regulation of transcription, but increasingly there has been a concentration on the post-transcriptional regulation of mRNAs via miRNAs, other small RNAs, and RNA …
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Untersuchungen zum Einfrier- und Auftauverhalten pharmazeutischer Humanproteinlösungen im Großmaßstab
… during large-scale freezing of pharmaceutical protein solutions. The stability of four protein bulk solutions during several freeze-thaw cycles was studied, in order to characterise two different large scale freezing systems and identify the specific stress factors. In the third part of the …
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Effect of 1B/1R Chromosomal Translocation on Dough Rheology of Soft Red Winter Wheat Flour
… samples from 1995-1996 were also analyzed for protein, ash, and moisture content, alkaline water retention capacity (AWRC), cookie diameter, tensile stress and strain, and by ¹³C nuclear magnetic resonance (¹³C-NMR) spectroscopy techniques. Significant (p = 0.0001) negative correlations were …