Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Protein mobility"”.
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Proteolethargy is a pathogenic mechanism in chronic disease
… that pathogenic signaling suppresses the mobility of a spectrum of proteins that play essential roles in cellular functions known to be dysregulated in these chronic diseases. The reduced protein mobility, which we call proteolethargy, was linked to cysteine residues in the affected …
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Influence of the cell wall on the organisation and dynamics of intracellular components in Arabidopsis Thaliana
… cell imaging of fluorescently labelled marker proteins to quantify the organisation and dynamics of the actin cytoskeleton and to determine if and how it was affected when the connection between the cell wall and plasma membrane was disturbed. Two image analysis techniques were developed to …
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Immunomodulation of Flavonoid Biosynthesis in Transgenic Arabidopsis thaliana
… in the phenotypic alterations was obtained from protein mobility shift assays. Taken together, the results indicate that scFv-mediated metabolic alteration is possible in plants. Thus, we show that intracellular expression of scFv's can be exploited as an additional tool for metabolic engineering.
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Protein spatiotemporal dynamics in gene regulation and disease pathology
A cell orchestrates billions of proteins to the right place at the right time to perform diverse cellular processes. Over the decades, this field has been evolving by integrating advances in microscopy, biochemistry, and molecular biology to unravel the intricate mechanisms governing protein …
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Physical Aspects of Min Oscillations in Escherichia Coli
… It consists of the MinC, the MinD, and the MinE proteins, which play an important role in the correct selection of the cell division site. The Min-proteins oscillate between the two cell poles and thereby prevent division at these locations. In this way, E. coli divides at the center, producing …
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Lamin A and lamin C are differentially dysfunctional in autosomal dominant Emery-Dreifuss muscular dystrophy
… gene which gives rise to lamin A and lamin C proteins by alternative splicing. These A-type lamins, together with B-type lamins, form the nuclear lamina, a network of intermediate filament proteins underlining the nuclear envelope. In order to ascertain the role lamin A and C separately …
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Terahertz spectroscopy to explore the role of vibrational dynamics in systems with varying structural order and disorder
… active biological molecules such as peptides, proteins, and antibodies need to be formulated and processed into dry powder form that can be reconstituted quickly in order to achieve long-term storage stability. The biomolecules retain their functional properties by embedding them into an …
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Modification of Lipid Microenvironments on Solid Support Structures for Use in Transmembrane Protein Assays
… cleaves both Notch-1, a transmembrane signaling protein, and Amyloid precursor protein (APP), a transmembrane protein whose cleavage may result in the formation of β-amyloid plaques in the brain. Notch-1 and APP are widely studied proteins that have substantial impacts on the development and …