Global ETD Search
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Showing 1 to 3 of 3 for “"Protein misfolding cyclic amplification"”.
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Use of the Protein Misfolding Cyclic Amplification for food safety and drug discovery
… fatal neurodegenerative disorders caused by the misfolding of the normal prion protein (PrP<sup>C</sup>) into its infectious form (PrP<sup>Sc</sup>). While the zoonotic potential of chronic wasting disease (CWD) remains uncertain, the presence of prions in food products raises public health …
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Development of A High-Throughput System For Screening of Anti-Prion Molecules
<p>The misfolded prion protein causes and transmits disease in both humans and animals. As other infectious agents, prions display strain variation, which can generate different pathological outcomes in affected individuals. Unfortunately, there are no known therapies for these diseases, which at …
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Prions Propagate as Dynamic Strain Mixtures
… other mammals. Prion disease is caused by the misfolding of a host encoded protein, PrPC, into the infectious conformation PrPSc. Phenotypic differences in disease (i.e., strains) have been observed for decades and are thought to be encoded by stain-specific conformations of PrPSc. There is …