Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"Protein membrane"”.
-
Computational Investigation of Protein-Membrane Systems Involved in Cellular Trafficking
"Living cells are enclosed by lipid membranes, and the inside of a cell is also subdivided into different functionally distinct membrane-bound compartments. To overcome the barrier the membranes pose for cellular trafficking between the outside and the inside, or between different compartments of …
-
Dynamics of protein-membrane interactions in drug metabolism and cancer
The cell membrane forms a critical barrier between the environment and the inner biochemical machinery of every life form on earth. Without the membrane, vital metabolic processes almost certainly could not occur. Many of these processes also require proteins present at or even embedded within the …
-
Predicting protein-membrane interfaces of peripheral membrane proteins using machine learning
Οι περιφερικές μεμβρανικές πρωτεΐνες αποτελούν βασικά συστατικά σε διάφορες βιολογικές διεργασίες, συμπεριλαμβανομένης της κυτταρικής διαφοροποίησης, του πολλαπλασιασμού και της διακυτταρικής επικοινωνίας. Οι πρωτεΐνες αυτές εμφανίζουν παροδική σύνδεση με τη λιπιδική διπλοστιβάδα και ρυθμίζονται …
-
Multiplex analysis of protein-lipid and protein-membrane protein interactions utilizing silicon photonic microring resonators
Reactions that occur at the cell membrane are varied and critical for many biological functions. When soluble proteins interact with the cell surface, the crowded and complex environment can act as a signaling mechanism and influence blinding and activity. Parsing out the components of the membrane …
-
Membrane and membrane protein dynamics studied with time-resolved infrared spectroscopy
Proteins are the machinery of the cell, performing functions essential for life. Proteins do not operate in isolation, however. Their function is intimately coupled to their environment; changes in this environment modulate the behavior of the protein. One of the most striking examples of …
-
Polyphosphate and tissue factor/factor VIIA as initiators of coagulation
Protein-membrane interactions are a critical component of the coagulation cascade. For many coagulation factors, these interactions are mediated via γ-carboxyglutamate rich regions, or GLA domains, in a Ca2+-dependent manner. Nearly all studies of GLA domain-containing coagulation factors, and …
-
Dynamic Molecular Mechanisms and Drug Design of Important Therapeutic Targets
Membrane proteins, such as G protein-coupled receptors (GPCRs), and soluble proteins play critical roles in a wide range of physiological and pathological cellular processes. GPCRs constitute the largest family of drug targets. The CXCR4 chemokine receptor, in particular, helps promote HIV entry …
-
The characterisation of calpain-like proteins in Trypanosoma brucei
… calpains and most of these novel calpain-like proteins are non-enzymatic homologues of typical calpains. The gene family is particularly expanded in ciliates and kinetoplastids, comprising 25 members in the parasite Trypanosoma brucei. Unique to kinetoplastids, some calpain-like proteins …
-
Atomic-level characterization of protein-lipid interactions using molecular dynamics simulations
Peripheral membrane proteins are structurally diverse proteins that are involved in fundamental cellular processes. Their activity of these proteins is frequently modulated through their interaction with cellular membranes, and as a result techniques to study the interfacial interaction between …
-
Examination of Brain-Fatty Acid Binding Protein Interaction with Hydrophobic Ligands and Micelles
Members of the fatty acid binding protein (FABP) family function as intracellular transporters of hydrophobic molecules, facilitating both fatty acid and lipid metabolism. FABPs share a common tertiary structure of beta barrel pocket for ligand incorporation with a flexible lid domain. Dysfunction …
-
A Simulation Approach to the Study of Bacterial Secretion Proteins
… of the structure and dynamics of cellular protein complexes is essential for understanding their functionally relevant interactions. In Gram-negative bacteria, the complex machinery associated with the type II secretion system (T2SS) polymerises inner membrane pseudopilin proteins into thin …
-
Anchoring Energy of Dengue E Protein into Host Membranes and Quaternary Assembly Depend upon Lipid Composition
… structural rearrangements of the envelope protein E leads to the formation of fusogenic E trimers that facilitate membrane fusion with late endosomes. The fusion mechanism is not fully understood, but poses as a key target for inhibiting the viral infection pathway. An important aspect of …
-
Investigation of the mechanism of transfer of a-tocopherol by the human a-tocopherol transfer protein (H-a-TTP) /
The human a-tocopherol transfer protein (h-a-TTP) is understood to be the entity responsible for the specific retention of a-tocopherol (a-toc) in human tissues over all other forms of vitamin E obtained from the diet. a-Tocopherol is the most biologically active form of vitamin E, and to date has …
-
Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
… is dedicated to investigating how specific protein-ligand interactions in the active site affect selectivity and affinity of inhibitors; how ATP-competitive inhibitors affect membrane binding of PI3Kα; how known membrane binding inhibitors of coagulation factor V and VIII C2 domains affect …
-
High-dimensional Data in Scientific Visualization: Representation, Fusion and Difference
… galaxy catalogs in astrophysics and protein membrane interaction in molecular dynamics. Each case required different computing power, ranging from personal computer to high performance cluster. Based on this experience across application domains, I propose a high-performance …
-
Interactions of Proteins with Membranes: Insights from Molecular Dynamics Simulations
Membrane proteins play a crucial role in numerous biological processes, including signal transduction, molecular transport, and cell recognition. Due to their involve- ment in fundamental physiological functions and their relevance as pharmacological targets, understanding their structure and …
-
Molecular and genetic studies on a SipD/IpaD-related virulence spike protein from immune-suppressive particles of a Drosophila parasitoid
… The EVs possess spikes and contain hundreds of proteins, some of which enable wasp eggs to escape encapsulation by changing the morphology and function of hemocytes, or killing them. Previous studies have identified an abundant surface/spike protein (SSp40) from <em>Leptopilina heterotoma</em> …
-
Structural Dynamics and Reaction Reversibility of Specific vs. Promiscuous Detoxification Enzymes
… the substrate-dependent structural dynamics of membrane-embedded CYP3A4 and CYP19A1, respectively, via hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations. Comparison of the structural dynamics of CYP3A4 bound to eight ligands reveals subtle and ligand-dependent …
-
AQUEOUS EXTRACTION OF OLEOSOMES FROM ISOLATED HULL-ENRICHED AND KERNEL-ENRICHED FRACTIONS OF CANOLA SEED
… naturally stabilized by a phospholipid–protein membrane and represent promising bio-based alternatives to synthetic emulsifiers. While canola (Brassica napus L.) is a major oilseed crop, limited information is available on how seed anatomy influences oleosome recovery, composition, and …
-
Structure and Function of HAMLET: Epitopes, Membrane Interactions and Molecular Recognition
… effect of HAMLET, (3) characterize the membranes response to HAMLET and the perturbation of membrane associated signaling cascades, (4) use proteomic screens to identify conserved features of HAMLET targets in tumor cells. Elucidating the structure of HAMLET is important to understand …
Page 1 of 2