Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Protein loss"”.
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The effect of condensed tannins on goats’ body weight
… Condensed tannins have a potential to bind proteins, reduce the feed intake and consequently reduce the body weight gain of goats. The study was conducted in order to determine the effects of different condensed tannin concentrations on the body weight gain of goats. The first experiment was …
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Optimization on Single-Pot, Solid-Phase-Enhanced Sample Preparation Method for Proteomics Workflow
… effective sample preparation to achieve accurate protein identification and quantification. Among current methods, Single-Pot, Solid-Phase-Enhanced Sample Preparation (SP3) is widely used because of its simple workflow, compatibility with different buffer systems, and suitability for low-input …
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The kinetics of albumin metabolism in experimental protein calorie malnutrition
Protein Calorie Malnutrition (PCM) is a term which embraces the broad spectrum of diseases occurring where diets are poor in protein. In most cases the diseases are due to an inadequate intake of utilizable protein. A small percentage of cases are due to excessive protein loss, (e.g. burns, …
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A potential route to hydrogel multifunctionalization utilizing encapsulation of acrylate-conjugated streptavidin
… chromatography (HPLC) and mass spectrometry. Protein binding was assayed through the use of rhodamine-labeled streptavidin and fluorescent microscopy. Gels were incubated overnight in solution to determine diffusion. After 7 days, PEG showed no diffusion while dextran acrylate demonstrated …
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Untersuchungen zum Einfrier- und Auftauverhalten pharmazeutischer Humanproteinlösungen im Großmaßstab
… during large-scale freezing of pharmaceutical protein solutions. The stability of four protein bulk solutions during several freeze-thaw cycles was studied, in order to characterise two different large scale freezing systems and identify the specific stress factors. In the third part of the …
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The role of recombinant human laminin-111 in adhesion-signaling and glycosylation in laminin-⍺2 deficient muscle
… in LAMA2 which encodes for the laminin-α2 protein. Loss of laminin-α2 results in the absence of laminin-211/221, an extracellular matrix protein essential for anchoring skeletal muscle cells to the basal lamina. LAMA2-CMD patients experience profound muscle weakness from birth, …
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Diagnostic and Prognostic Biomarkers for Early Prostate Cancer
… by focusing on DNA methylation, and PTEN and ERG protein markers in a large biomarker study. During this study we overcame several technical challenges associated with a typical biomarker discovery/validation approach such as cohort development and sample collection, and recovery of high-quality …
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Characterization and Cell-Seeding of Decellularized Adipose Tissue Foams for Wound Healing
… of equilibrium water content, porosity, protein loss, and swelling ratio (n = 3), with the aim of elucidating how protein concentration and tissue processing affect foam properties. DAT foams were hydrophilic, porous, and maintained their form in culture despite the gradual loss of …
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
… a correlation between HAND and reduced protein expression of brain heme oxygenase-1 (HO-1), a highly inducible detoxifying enzyme with antioxidant and anti-inflammatory functions. We further demonstrated that HIV infection of macrophages reduces HO-1 RNA and protein and that this HO-1 …
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Role of mural Cx43 in vascular interactions and its regulation by breast tumor cells
… breast tumor cells downregulates Cx43 mRNA and protein to release endothelial cells from mural cell-mediated growth inhibition. We also report that Ang-Tie signaling is involved in tumor induced Cx43 loss and release of endothelial proliferation. Since Cx43 function and half-life can also be …
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Testing roles of Hereditary Spastic Paraplegia genes in axonal endoplasmic reticulum modelling in Drosophila
… within the axon; common mutations in HSP affect proteins of the spastin, atlastin, REEP and reticulon (RTN) families, which possess hydrophobic hairpin domains in the ER membrane to help confer curvature on tubular ER. Drosophila mutants lacking members of RTN and REEP families exhibit partial ER …
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Role of retinoblastoma protein in the development of liver cancer
… in the progression of the disease. The impact Rb loss has on the development of liver cancer was determined using an in vitro system, with Cre-lox technology. The Cre-lox technology enables the lethality of Rb loss in the embryo to be overcome. The regulation of p53, extent of DNA damage and cell …
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Pseudomonas aeruginosa OprD-Family Porins Facilitate Imipenem Translocation Resulting in AmpC β-Lactamase Induction Contributing to the Effectiveness of Imipenem/Relebactam
… impact relebactam had on imipenem MICs. However, loss of OprD correlated with imipenem nonsusceptibility. Protein production was the strongest indicator and resolved discordant phenotypes observed in isolates when only transcript levels were taken into consideration. AmpC induction occurred upon …
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Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.
… neuron (SMN1) gene and is marked by motor neuron loss and muscle weakness. While its genetic basis is clear, the underlying molecular mechanisms remain elusive. Decreased levels of the survival of motor neuron (SMN) protein, encoded by the SMN1 gene, are implicated in SMA pathology. Despite …
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Reconstruction of milk fat globules/membrane (MFGs/MFGM) and characterization of its physicochemical properties and techno-functionalities
… and milk fat globule membrane (MFGM) proteins. To mimic human milk's lipid profile, MFGs/MFGM ingredients from sweet whey or buttermilk are fortified in IF. Understanding the structural and compositional, and techno-functionalities changes of MFGs/MFGM is crucial for their application. …
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Isolation and classification of proteolytic bacteria from the bovine rumen
… are later synthesized to digestible microbial proteins of higher biological value than the feed protein, or conversely this activity may be detrimental because of net protein loss. In spite of the nutritional significance of this activity the proteolytic ruminal bacteria have received …
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Characterizing PIAS1 Function During Embryogenesis and Lung Cancer Progression
… cell lung cancers (NSCLC). The SUMO E3 ligase protein inhibitor of activated STAT-1 (PIAS1) is one the few known SUMO conjugating enzymes known to date. PIAS1 was first discovered as a negative regulator of signal transducer and activator of transcription 1 (STAT-1), from which its name is …
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Cellular Mechanism of Exocrine Pancreatic Insufficiency in Diabetes Mellitus
… of regulation. Obvious candidates are ligand proteins involved in stimulating secretion, receptor defects, intracellular ion levels and post-receptor signal transduction encompassing transcription and translation. To address these points, the current studies aimed to characterise the effects …