Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 239 for “"Protein kinases"”.
-
Protein phosphatases and protein kinases in dictyostelium
… behavior and partial characterization of 5 protein phosphatases, 6 paranitrophenyl phosphate (pnpp) phosphatases and 2 protein kinases from <i>Dictyostelium</i> are described. .Two of the protein phosphatases are shown to have subunit structures. All of the protein phosphatase activities …
-
Protein kinases in hormonal regulation of adipocyte metabolism.
… are regulated by cellular signaling, and kinases are central enzymatic players in hormone-induced cellular signaling. A dysfunctional adipose tissue can contribute to insulin resistance in many obese individuals. Therefore it is important to elucidate the cellular mechanisms that govern …
-
Protein kinases that phosphorylate 14-3-3 isoforms
… -3 is an abundant, predominantly phospho-binding protein, intimately involved in the regulation of many diverse signal transduction events including cell cycle regulation, nucleo-cytoplasmic targeting of essential transcription factors and regulation of catecholamine synthesis. The 14 -3 -3 family …
-
Regulation of Toxoplasma Motility by Calcium-Dependent Protein Kinases
… and plants, possess calcium-dependent protein kinases: CDPKs) that are directly activated by calcium binding and have been proposed to participate in the transduction of calcium signals. A number of CDPKs are conserved among apicomplexans, and showed distinct subcellular localizations …
-
Protein kinases: Structure modeling, inhibition, and protein-protein interactions
<p>Human protein kinases belong to a large and diverse enzyme family that contains more than 500 members. Deregulation of protein kinases is associated with many disorders, and this is why protein kinases are attractive targets for drug discovery. Due to the high conservation of the ATP binding …
-
Targeting protein kinases to manage or prevent Alzheimer’s disease
… researched. One such strategy is to modulate protein kinases such as cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase-3 (GSK-3α and GSK-3β), and the protein kinase RNA-like endoplasmic reticulum kinase (PERK). AD intervention by reduction of amyloid …
-
Pharmacological Modulation of Macrophage Cytotoxicity: Role of Protein Kinases
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1987.
-
Regulation Of Cyclic-amp-dependent Protein Kinases During Skeletal Myogenesis
… The regulation of the levels of cAMP-dependent protein kinases during myogenesis in L6 was studied, as these enzymes have been proposed to be involved in the control of this process. Measurement of the mRNA levels for the type I regulatory subunit (R{dollar}sb{lcub}rm I{rcub}{dollar}) of …
-
Regulation of Protein Kinases (Syk and PKC zeta) in platelets
… in platelet clot or thrombus formation. The protein kinase family of enzymes mediates a significant number of these intracellular signaling events that culminate in platelet activation. These enzymes can be broadly classified into two classes- tyrosine kinases and serine/threonine kinases. …
-
Regulation of human protein kinases and phosphatases by 14-3-3
… thesis shows that a previously-uncharacterised protein FAM122A and its paralogue FAM122C form stable stoichiometric complexes with the protein phosphatase 2A (PP2A) heterotrimer (AαB55αC). Moreover, the FAM122A–PP2A complex is active and contains methylated catalytic C subunit. In contrast, a …
-
Regulation of blood platelet function by the AGC family of protein kinases
… in the activation of the AGC family of Ser/Thr protein kinases (PKA, PKG and PKC). Once activated these kinase blunt platelet function through the phosphorylation of signalling proteins requested for activation. In this study, the role of AGC family kinases and their signaling cascades in …
-
Regulation of hnRNP A1 Cellular Localization by Protein Kinases and its Biological Impact
… Ribosome Entry Sites (IRES) to drive viral protein synthesis. IRESs are specialized RNA elements present within the 5’ UTR of mRNAs that recruit ribosomes independently of the 5’ m7G cap structure. hnRNP A1 (heterogeneous nuclear ribonucleoprotein A1), a multifunctional RNA binding protein, …
-
Molecular cloning of three genes encoding SNF1/AMPK protein kinases from Drosophila melanogaster.
… and the SNF1 gene, encoding a serine-threonine protein kinase, has the essential function of releasing genes from glucose repression in response to glucose starvation. SNF1 homologues have been found in a number of different organisms and recent molecular and biochemical evidence has revealed …
-
Rat liver nuclear envelope insulin binding and its effects on endogenous protein kinases
… ATP - binding of nuclear envelope ATP - binding proteins. The latter would demonstrate a primary effect of insulin i.e. the modulation of the ATP - binding capacity of identified NTPases / protein kinases (or their release from some inactive storage form), and not a general phenomenon such as …
-
Novel peptide-based approaches to study the activity and substrate specificity of protein kinases
Protein phosphorylation, catalyzed by protein kinases, is the predominant post-translational modification made to proteins. This process is readily reversible, with protein phosphatases catalyzing removal of the installed phosphate groups. Together, protein kinases and phosphatases modulate the …
-
Calcium -dependent protein kinases are myristoylated and associated with different membranes in Arabidopsis thaliana
<p>In plants, calcium-dependent protein kinases (CDPKs) are the predominant calcium-stimulated kinases and are known to be involved in many cellular processes. CDPK enzymatic activity previously has been detected in many locations in plant cells, including the membrane fraction. However, little is …
Page 1 of 12