Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Protein kinase D"”.
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Receptor-Mediated Hypertrophic Signaling Via Protein Kinase D and Histone Deacetylase 5 in Adult Myocytes
<p>Hemodynamic stress and neurohumoral signaling are common causes of cardiac hypertrophy. These extrinsic stress stimuli typically act on GPCR and induce a cascade of signal transduction to re-program terminally differentiated myocytes to grow in length or width. The compensatory hypertrophic …
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Functional Interactions Between Par-1b Protein Kinase and RNF41 E3 Ubiquitin Ligase
<p>The Par-1 family of serine/threonine protein kinases functions to regulate cell polarity and is conserved from yeast to humans. Par-1 is encoded by one of six Par: partitioning-defective) genes: Par-1-6) originally identified in a genetic screen conducted in Caenorhabditis elegans: C. elegans). …
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Exploring the Role of PKD Enzymes in the Innate and Adaptive cells of the Mammalian Immune System
Protein kinase D (PKD) enzymes are a family of serine/threonine kinases that belong to the calcium/calmodulin-dependent kinase superfamily. Recently, a role for PKD enzymes has been established in the adaptive immune system where murine PKD2 was shown to be essential for normal peripheral CD4+ and …
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Regulation of β2-integrins by signalling pathways and cytoplasmic interacting partners
… It was now shown that B cells do not require Protein Kinase C βeta or Protein Kinase D for integrin-mediated cell adhesion but inhibition of Phosphoinositide 3-kinase and Akt reduced chemokine-(Stromal cell-Derived Factor 1-) induced B cell adhesion to the LFA-1 integrin ligand ICAM-1 …
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Inhibition of AMPK via phosphorylation at Ser485/491: multiple mechanisms of regulation
AMP-activated protein kinase (AMPK) is an energy-sensing enzyme that is activated when cellular energy is low and causes muscle and other cells to increase glucose uptake and fat oxidation, diminish lipid synthesis, and alter expression of various genes. AMPK activity is diminished in animals with …