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Showing 1 to 20 of 349 for “"Protein folding"”.
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Cellular influence on protein folding
Advances in the study of protein folding and structure have greatly expanded our understanding and ability to predict and modify protein structure and, increasingly, even function. Attention has now turned to developing a better understanding of how protein structure, function, and folding interact …
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Glassy models of protein folding
… the physics of disordered materials to study protein folding. The first chapter consists of a general introduction to proteins and protein folding. In Chapter Two we develop a simple protein folding model and use a random energy approximation to calculate its equilibrium properties. The model …
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Energy Landscapes for Protein Folding
Proteins are involved in numerous functions in the human body, including chemical transport, molecular recognition, and catalysis. To perform their function most proteins must adopt a specific structure (often referred to as the folded structure). A microscopic description of folding is an …
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Investigation Into Protein Folding and Misfolding
<p>Proteins are the fundamental building blocks of all living organisms. They are critical in the proper function of virtually all cellular processes and without them biological life would be impossible. Since their discovery, understanding the transition of DNA to functional protein has been …
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Chain dynamical theories of protein folding
Completely microscopic theories of protein folding must take into account chain dynamics. The energy landscape description of protein folding accommodates two rather distinct behaviors of the polypeptide chain: the glassy dynamics expected for heteropolymers with random interactions and the …
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Evolutionary Constraints Specifying Protein Folding and Function
Proteins are complex macromolecules that carry out biological functions while under constant mutational load and selective pressure during evolution. Consequently, evolution has generated protein families by exploring the set of sequences able to carry out a particular biological activity, …
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Structural biology of GroEL assisted protein folding
… of molecular chaperone that assists the re-folding of many misfolded proteins (SP). Recent kinetic analyses revealed a new paradigm of how GroEL/ES uses ATP to assist protein folding. Following these pioneering biochemical studies, I address two fundamental questions related to …
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Exploring Downhill Protein Folding Free Energy Landscapes
Downhill protein folding, i.e., folding with the free energy barrier comparable to the thermal energy kBT, is investigated by combining laser induced temperature-jump kinetics measurements and Langevin dynamics simulations. A kinetic and thermodynamic survey of multiple WW domain mutants is …
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Mutagenic effects on protein folding and stability
… sequence information dictates the formation of protein structure is critical for accurate prediction of structure, for de novo protein design, and for understanding protein folding and misfolding. Based on extensive studies in peptide and protein systems, the pattern of polar and nonpolar amino …
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Oxidative Protein Folding Pathways In Gram-Positive Actinobacteria
… are important for the stability of many secreted proteins. These covalent linkages, which result from the oxidation of neighboring cysteine (Cys) residues, are often rate-limiting steps for protein folding and maturation. Disulfide bond formation is restricted to extracellular oxidizing …
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Monte Carlo approaches to the protein folding problem
The excluded volume of a polymer is defined and calculated by Monte Carlo integration. The excluded volume for a polymer with another polymer of the same length scales as N1.74. These results agree with theoretical predictions about the behavior of polymers in the dilute solution regime. The …
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Barrier Heights and Diffusion Coefficients in Protein Folding
A widely held view with respect to the folding of single-domain proteins is that they are two-state. In other words, it is seemingly sufficient to invoke just two thermodynamic macrostates - folded and unfolded - to explain the experimental data with a transition-state like picture. Unfortunately, …
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Protein folding in living cells and under pressure
Protein folding, the process through which proteins gain their functional structure, can be approached from the perspective of many disciplines. Starting with biology, we can probe how protein structure relates to function and consider how the fold of a protein interacts with the biological …
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Protein folding in crowded environments and living cells
… to bridge this divide by performing studies of protein folding in in vitro crowded environments and in living cells. We begin by investigating the thermodynamic and kinetic behavior of the proteins in protein/carbohydrate matrices, and find significant differences compared to dilute, buffer …
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Analysis of Molecular Dynamics Simulations of Protein Folding
… physiological timescales over which many small proteins fold, all atom MD simulations of protein folding are now becoming popular. To distill features of such large folding trajectories, we must develop methods that can both compress trajectory data to enable visualization, and that can yield …
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Behavioral analysis and protein folding in zebrafish larvae
… using zebrafish as the model organism, I studied protein folding dynamics in differentiated tissues in a living organism. With CPLC postdoc Caitlin Davis, I developed a customized pipeline that integrates meganuclease-mediated mosaic transformation with fluorescence-detected temperature-jump …
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The role of hydrophobic core in protein folding
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1991.
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Protein Folding, Host Cell Proteostasis, and Viral Evolution
… non-conservative amino acid substitutions cause protein folding defect. Mutations that result in substantial protein folding defects cannot be tolerated, regardless of how adaptively beneficial the resultant protein variant otherwise would be. Importantly, in cells, protein folding is assisted by …
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Translation rate is genetically encoded and influences protein folding
… of these so-called synonymous codons among protein coding sequences is not random and multiple theories have arisen to explain the biological significance of such non-uniform codon selection. Many ideas revolve around the notion that certain codons allow for faster or more efficient …
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Applications of Funneled Landscapes: Protein Folding and Molecular Recognition
… functional model is formulated to describe protein folding which includes a specific potential, a polymer chain entropy, and explicit physically motivated cooperativities. The functional is applied to a range of protein systems in order to characterize their folding funnels. General features …
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