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Showing 1 to 1 of 1 for “"Protein farnesyl transferase"”.
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Synthetic strategies for potential trypanocides
… Trypanosomes have a variable surface glycoprotein (VSG) coat, which allows them to evade the human immune system. The GPI anchor attaches the VSG to the cell membrane; therefore inhibiting GPI synthesis should expose the parasite to the immune system. Initially, large substrate analogues …