Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Protein encapsulation"”.
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CHITOSAN PARTICLES FOR THE CONTROLLED RELEASE OF PROTEINS
… chitosan micro or nanoparticles to delivery proteins. What are the questions this thesis attempted to solve? 1) What are the proper preparation conditions of chitosan micro or nanoparticles? 2) How does the pH value affect the formation and protein encapsulation of chitosan nanoparticles? 3) …
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Stability of proteins within biodegradable microspheres
… been extensively studied for controlled-release protein delivery. However, significant issues arise in formulating such delivery systems since few proteins have been successfully encapsulated and released from these microspheres. Here, methods are developed to determine the causes of protein …
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Development of polymeric nanoparticulate formulation encapsulating protein molecules following hydrophobic ion pairing complexation
… release nanoparticulate based dosage form for protein therapeutics represents a real challenge to scientists. These protein molecules are prone to denaturation under stress conditions such as sonication and presence of organic solvents. Another limiting factor in developing nanoparticulate …
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Development of polymer and lipid materials for enhanced delivery of nucleic acids and proteins
… therapeutics such as nucleic acids and proteins could potentially catalyze the clinical translation of many gene and protein-based therapies. However, progress has been hindered by a lack of safe and effective materials and by insufficient insight into the relationship between key …
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Fluorescence photophysics, characterisation and application of labelled glucose/galactose binding protein
… sensor is bacterially-derived glucose binding protein (GBP). In this project, the modified triple mutant H152C/A213R/L238S-GBP (mGBP) was investigated for viability as a functioning glucose sensor. Labelling the protein with the environmentally-sensitive dye BADAN produced repeatable, nearly …
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Development and physical characterisation of polyethylene glycol glycerides-based gel formulations for macromolecule delivery
… advantages on enhancing the bioavailability of protein/peptides. Gelucire 50/13 is a complex mixture of glycerides and PEG. It is mainly used in solid oral formulations for delivering small molecular weight drugs. The purpose of this project was to develop novel uses of Gelucire as a liquid …
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Development of nanoparticles for oral delivery of insulin
… remains the mainstay of drug administration for protein therapeutics. However, for diseases that require frequent drug dose over long periods of time, injections can result in patient incompliance and poor treatment outcomes. For such diseases, oral drug delivery is the most non-invasive and …
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Investigation of properties affecting controlled release of macromolecules from PLGA microspheres
… of sizes for different methods of delivery. The encapsulation, stability, and release profiles of therapeutic release based on physical and thermodynamic properties has also been studied and modeled to an extent. Much research has been devoted to tailoring formulations for improved therapeutic …