Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Protein damage"”.
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EFFECT OF WATERCRESS EXTRACT AND KAEMPFEROL AGAINST OXIDATIVESTRESS
… affecting biomolecules such as DNA, proteins, and lipids. The therapeutic potential of watercress (Nasturtium officinale) ethanol extract and kaempferol against hydroxyl radical-induced oxidative damage on human serum albumin (HSA) was investigated. Hydroxyl radicals, the most …
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A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression
… DNA, recruitment of coregulatory proteins, and modification of estrogen responsive genes. Because DNA-induced conformational changes in ERalpha structure alter complex formation, we were interested in identifying proteins associated with the ERE-bound receptor. Using a novel …
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Inactivation mechanisms of human norovirus surrogate Tulane virus by peracetic acid at different pHs
… whether the inactivation was caused by the damage of the genome or the protein capsid or both. The genome damage was revealed by quantifying the viral intact genome using the reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR). The capsid proteins degradation is …
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Cardiomyocyte Autophagy Is Induced by Protein Aggregation in Heart Disease
… generation of reactive oxygen species, protein damage, and protein aggregation in the acute period of pressure overload. Given the simultaneous presence of autophagosomes and aggregates, and autophagy's role in bulk degradation, I postulated these events were mechanistically linked. I …
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Hypochlorous Acid Mediated Damage of Chromatin
… neutrophils at sites of inflammation, can damage both DNA and associated histone proteins. HOCl damage to cytosine bases in DNA generates the chlorination damage products 5-chlorocytosine (ClC) and 5-chlorouracil (ClU) as well as the oxidation damage products 5- hydroxycytosine (HOC) and …
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On aging and the role of Ubp3 in heterochromatic gene silencing and protein quality control
Aging is characterized by a build-up of damage in organisms ranging from protists to multi-cellular species. This damage adversely affects core components such as DNA and proteins which are necessary to sustain life. Remarkably, as an old yeast cell divides, its daughter cell is fully rejuvenated …
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Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model
… pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative diseases. However, more recent work has begun to suggest that the formation of ordered inclusions serves …
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The mechanism by which manganese protects Escherichia coli from hydrogen peroxide
… the substitution of manganese may prevent protein damage. Accordingly, during H2O2 stress, mutants that cannot import manganese and/or are unable to sequester iron suffer high rates of protein oxidation. To directly test our hypothesis, I studied three functionally distinct mononuclear …
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Interactions between oxidative stresses in corn
… resulting in cellular membrane oxidation, protein damage and reduced crop productivity. Along with the rise in ozone concentration, changing disease patterns can bring together environmental factors that had previously not been expected to interact. In order to look at the possible …
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The role of a deglycating enzyme ‘fructosamine-3-kinase’ in diabetes and COPD
… haemoglobin in erythrocytes and other glycated proteins in other tissues. FN3K acts through phosphorylation of fructosamines on the third carbon of their sugar moiety, making them unstable and consequently causing them to detach from the protein. The degree of deglycation is thought to depend on …
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Disinfection of fresh produce contaminated by enteric viruses and their inactivation mechanisms
… on viruses were also investigated to reveal that damage on both genome and binding proteins caused by free chlorine led virus inactivation. RV lost its ability to bind to host receptors after exposure to free chlorine at 1.7 ppm for 1 min. For the same level of binding reduction of TV, free …
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Protein Engineering for Biomedical Materials
The inherent design freedom of protein engineering and recombinant protein production enables specific tailoring of protein structure, function, and properties. Two areas of research where protein engineering has allowed for many advances in biomedical materials include the design of novel protein …