Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Protein biophysics"”.
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Protein Biophysics in Hollow-Core Photonic Crystal Fibres: Label-Free Monitoring of Biomolecules in Optofluidic Waveguides
Proteins are the central building blocks of life, and experimental methods for their study are fundamental to deepening our under- standing of biology and the life sciences. When studying protein interactions, we seek new experimental methods that can detect and monitor proteins in solution, at …
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Investigation of the Discoipyrroles and Other Marine Bacteria Derived Natural Products
… the fields of ecology, industrial chemistry, and protein biophysics. This work will demonstrate how the discoipyrrole family of natural products inspired novel biomedical and biosynthetic discovery. In particular, their biosynthesis features unique mechanisms that are independent of protein …
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The structure and function of TasA in the <i>Bacillus subtilis</i> biofilm matrix
… polysaccharides, lipids, nucleic acids and proteins. Some of the proteins found within the matrix are polymeric, with examples including the flagellum, pilus and amyloid-fibres. There is a growing list of proteins in the matrix that are categorised as “amyloid-like”, including the …
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Design and development of novel antagonists targeting Cdc20, a central regulator of the Anaphase-Promoting Complex/Cyclosome, for the treatment of cancer
… 20 (Cdc20), a central SAC regulator and mitotic protein, binds the Anaphase-Promoting Complex/Cyclosome (APC/C), a complex capable of stipulating protein destruction, regulating its activity and driving cell cycle progression through orderly APC/C substrate degradation. Key oncogenic roles and …
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Computational methods to design biophysical experiments for the study of protein dynamics
… and data acquisition. In the field of protein biophysics, computational simulations such as molecular dynamics and spectroscopy-based experiments such as double electron-electron resonance and Fluorescence resonance energy transfer techniques have emerged as critical experimental tools …
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Force-dependent changes in alpha-catenin conformation
… binding of α-catenin to the actin-binding protein vinculin and to the actin cytoskeleton itself. This regulation is accomplished through distinct conformational changes in the α-catenin central modulatory (M) domain and the C-terminal actin-binding domain (ABD), respectively. Force-induced …
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Understanding protein misfolding diseases through the development of biophysical methods
… these findings in the context of a-synuclein, a protein closely associated with Parkinson’s disease. Taken together, these results illustrate the opportunities offered by combining in vitro aggregation assays with in vivo aggregation kinetics. Finally, we explored several natural compounds in …
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Advances in biophysical characterisation through micron scale flow engineering
Proteins are the chief actor molecules of cells central to the majority of biochemical and biophysical processes that sustain life. Interactions between proteins and other biomolecules are crucial to a faultless execution of biological function, yet it has remained challenging to analyse these …