Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 179 for “"Protein aggregation"”.
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Order, disorder, and protein aggregation
Protein aggregation underlies a number of human diseases. Most notably, it occurs widely in neurodegenerative diseases, including Alzheimer's and Parkinson's. At the molecular level, neurotoxicity is thought to originate from toxic gains of function in multimeric aggregates of proteins that are …
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Mechanisms of protein aggregation and refolding
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1991.
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Novel Fluorescence Techniques to Probe Protein Aggregation
The self-assembly of amyloidogenic proteins to form cytotoxic species that give rise to brain deterioration underlies numerous neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Increasing evidence indicates that it is the rare, low-molecular-weight species (oligomers) rather …
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Effects of system complexity on protein aggregation in neurodegeneration
… loss, and the accumulation of two types of protein aggregates: amyloid β (Aβ) plaques and tau neurofibrillary tangles. The deposition of Aβ can be causally linked to familial and early onset AD, however Aβ-targeting treatments against the more common sporadic form of the disease have so far …
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Quantitative studies in effects of additives on protein aggregation
Rational design of protein additives has been limited by the understanding of mechanism of protein and additive interaction. In this work we have applied molecular dynamics with all atom potentials in order to study the thermodynamic effect of additives on proteins. The method is based on …
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Rational design of additives for inhibition of protein aggregation
Protein based therapeutics hold great promise in the treatment of human diseases and disorders and subsequently, they have become the fastest growing sector of new drugs being developed. Proteins are, however, inherently unstable and the degraded form can be quite harmful if administered to a …
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Targeted magnetic nanoparticles for remote manipulation of protein aggregation
… (MNPs) selectively attached to their target proteins can be used to manipulate and break up toxic or obstructive aggregates. We applied this magnetic hyperthermia treatment to the amyloid beta (A[beta]) peptide, which unnaturally folds and self-assembles forming amyloid fibrils and insoluble …
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BUILDING A MODEL TO SIMULATE PROTEIN AGGREGATION AT ATOMISTIC DETAIL.
… of a computational method to simulate protein aggregation into amyloids. As further described below, protein aggregation is a complex process leading to the accumulation and deposition of amyloid fibrils causing several and uncurable diseases. The atomistic detail of this process …
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Cardiomyocyte Autophagy Is Induced by Protein Aggregation in Heart Disease
… generation of reactive oxygen species, protein damage, and protein aggregation in the acute period of pressure overload. Given the simultaneous presence of autophagosomes and aggregates, and autophagy's role in bulk degradation, I postulated these events were mechanistically linked. I …
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Influence of Kaempferol on Noncanonical DNA Structures and Protein Aggregation
<p>Therapeutic<strong> </strong>potentials of phytochemicals have attracted much attention in medicinal chemistry. Kaempferol (KMP) is a naturally occurring plant flavonoid found in leafy greens such as watercress, kale, and broccoli. Interestingly, KMP has been shown to exhibit anticancer …
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Bayesian Approaches for the Mechanistic Analysis of Protein Aggregation Kinetics
… approach to account for the stochastic nature of protein aggregation. Stochastic effects affect amyloid formation in two main ways, namely through (i) variability at the molecular level and (ii) the macroscopically apparent variation in the rates of repeated experiments. Bayesian statistics …
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Characterization of Oxidized Tau Protein Aggregation and Inhibition of Tau Aggregation via MAP2
… (NFT) composed of the microtubule stabilizing protein Tau are a pathological hallmark of Alzheimer's disease (AD) and many other dementia related diseases specified as Tauopathies. Due to alternative mRNA splicing, intrinsically disordered Tau exists as six separate isoforms in the adult human …
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Mitigating protein aggregation to reduce the toxicity inherent to Parkinson’s and Alzheimer’s diseases
Protein deposition in the form of amyloid fibrils is the hallmark of more than 40 human pathologies, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Misfolded protein oligomers formed as intermediates during the aggregation process have been strongly implicated in the onset and …
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Biophysical approaches to characterising protein-protein interactions and intermediate species in protein aggregation
The phenomenon of protein misfolding and aggregation has been associated with over 50 human diseases, including Parkinson’s disease (PD). While the hallmark deposits in aggregation-associated diseases are primarily composed of fibrillar species, intermediate oligomeric species that form during the …
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Investigating the role of protein aggregation in neurodegenerative diseases using super-resolution imaging
… loss of neuronal tissue accompanied by protein aggregation in the brain. Although identified as a leading pathology, the role of protein aggregates in the pathogenesis remains elusive. They are a highly heterogeneous population spanning from the fibrous forms visible in histology to the …
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Two-photon fluctuation correlation spectroscopy: Method and applications to protein aggregation and intracellular diffusion
Fluctuation correlation spectroscopy (FCS) is an experimental technique for the study of hydrodynamics and molecular interactions of microscopic systems. The method monitors the statistical behavior of spontaneous equilibrium fluctuations in number occupation of a fluorescent species in a subvolume …
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Fluorescence lifetime imaging microscopy to study protein aggregation in the context of neurodegenerative diseases
Neurodegenerative diseases are associated with protein misfolding and amyloid aggregation. The work presented in this thesis involves the use of fluorescence lifetime imaging microscopy (FLIM) and other biophysical techniques to elucidate the molecular mechanisms that underlie different …
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Systematic development of rationally designed antibodies targeting predetermined epitopes of interest and protein aggregation
… associated with the process of misfolding and aggregation of proteins. Therefore, modulating the aggregation pathway of disease-related proteins, in particular the Amyloid-β peptide (A) in Alzheimer’s disease and α-Synuclein (αSyn) in Parkinson’s disease, is key to establishing therapeutics …
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