Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Protein aggregate"”.
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The Development and Application of Ultra-sensitive Protein Aggregate Detection Techniques
… of ultra-sensitive techniques for detecting protein aggregates. It begins by studying the role of apolipoprotein E (apoE) in amyloid- β (Aβ) pathology in Alzheimer’s disease (AD). The isoform-specific and lipidation-specific behaviours of apoE and the co-aggregates formed with A β are …
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Aneuploidy causes proteotoxic stress in Saccharomyces cerevisiae
… strains are prone to aggregation of endogenous proteins as well as of ectopically expressed hard to fold proteins such as polyQ stretch-containing proteins. Prion conversion rates are also increased in most aneuploid yeast strains. Protein aggregate formation in aneuploid yeast strains is likely …
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Evaluating suspected CWD feral pig brain samples using RT-QuIC and protocol for the purification and quality control of recombinant monomeric proteins for RT-QuIC assay
<p>Proteinopathy is a broad term used to describe any disease or condition that arises as</p> <p>a result of aberrant protein behavior. Most often it is used when discussing any of a wide</p> <p>range of neurodegenerative diseases that tend to result from an abnormal misfolding and</p> …
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Exploring the role of Leucine Rich Repeat Kinase 2 within the innate immune system
Leucine rich repeat kinase 2 (LRRK2) is a 286 kDa protein expressed in a variety of tissues and cell types, including neuronal tissue and innate immune cells. Mutations in LRRK2 have been linked to inflammatory diseases, most notably Crohn’s disease and Parkinson’s disease. Further to this, LRRK2 …
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An interdisciplinary approach to studying mechanistic, structural and toxic features of protein aggregates associated with neurodegenerative disorders.
The misfolding and aggregation of proteins is closely associated with more than fifty human disorders, including Alzheimer's and Parkinson's diseases, all of which are currently incurable and many represent a major threat to human life. The mechanism of protein aggregation is subject to extensive …
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INVESTIGATING THE ROLE OF SNAP29 AND THE AUTOPHAGY PATHWAY IN DROSOPHILA MELANOGASTER MODELS OF C9ORF72 - LINKED ALS/FTD.
… pathway, responsible for clearing damaged proteins and organelles, progressively declines in normal aging and in neurodegenerative diseases, leading to toxic protein aggregate accumulation. Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating …
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A Bottom-Up Approach to Building an Artificial Cell by Self-Assembly
… can be formed. The self- assembly of proteins in cells is required for normal biological function and unintended self-assembly also can occur following a change in environmental conditions, in some cases leading to disease. To understand these processes more fully, experiments …
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The Effects of Aging on EGFR/pSTAT3-Dependent Gliovascular Structural Plasticity
… which is comprised, in part, of tight junction proteins such zonula-occludens-1 (ZO1) (6) and Claudin-5 (7). Underlying the execution of these processes is the morphological and spatial arrangement of astrocytes between neurons and endothelial cells comprising blood vessels, where …