Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Protein adducts"”.
-
Free radical mediated mechanisms in stress and development in in vitro crop plant systems
… technique, for the detection of hydroxynonenal-protein adducts in plant extracts. This study shows for the first time, in plants, that exogenously applied lipid peroxidation products hydroxynonenal (HNE) and malondialdehyde (MDA) inhibit callus proliferation and development (as somatic …
-
DEVELOPING CHEMICAL TOOLS TO MAP MOLECULAR MECHANISMS THAT DRIVE DISEASE
… DNA encodes for cellular instructions and proteins execute these genetic protocols to ensure the cell’s components are functioning properly. Thus, the underlying biochemistry within the cell is tightly regulated to ensure vitality. However, when these processes become compromised or …
-
Comparison of Redox-Active and Conjugative Enzymes With and Without Efflux Transporters and Their Comparative Effectiveness in Protection Against Cellular Toxicity of 4-Hydroxy-2-Nonenal (HNE), an Aldehyde Lipid Peroxidation Production
… strong protection against HNE cytotoxicity, protein adduct formation, and GSH depletion. AKR1C1 and GST 5.7 failed to protect against these endpoints. The hemi-acetal ring of the HNE-SG conjugate can break to form an open chain aldehyde-SG, which can be cytotoxic by reacting with cellular …
-
STUDIO DEGLI ADDOTTI CATECOLAMMINE-PROTEINE IN SOSTANZA NERA E NEL PUTAMEN UMANI
… cysteine, glutathione, or cysteine residues of proteins. Since cysteine residues are often localized in the active site of the enzyme, the adduct between dopamine-quinone and cysteine may alter the protein function and thus become a potential neurotoxic factor for the cellular life. In order to …
-
Chlorogenic and Caffeic Acids’ Impact on Formation of Fluorescent and Non-Fluorescent Advanced Glycation End-Products as a Function of Temperature
… with dicarbonyl intermediates and formed quinone-protein adducts, as well as CGA’s higher antioxidant capacity due to having more hydroxyl groups. In contrast both CGA and CA enhanced AGE formation the most at 63 °C, compared to 25 °C and 100 °C likely due to the formation of pro-oxidants from the …
-
N⁶-formylation of lysine : a pathological secondary modification of proteins
There is increasing recognition that aberrant protein modifications play an important role in the pathophysiology of inflammation and oxidative stress in cells. We recently discovered that N⁶-formylation of lysine is an abundant endogenous modification of histone and chromatin proteins. The high …
-
LATE PROTECTIVE EFFECTS OF NETRIN-1 AND ADENOSINE A2B RECEPTOR ACTIVATION IN THE MURINE ACETAMINOPHEN HEPATOTOXICITY MODEL
… of C57BL/6N mice was caused by forming more APAP-protein adducts and subsequent enhanced mitochondrial dysfunction associated with aggravated nuclear DNA fragmentation. In the second study, we demonstrated that the neuronal guidance protein netrin-1 could attenuate APAP hepatotoxicity in mice at …
-
A Study on the Protein Interaction with Different Platinum Compounds
… histidine and cysteine to form cisplatin-protein adducts which are responsible for most of its cytotoxicity and side effects. Recent articles on cisplatin-protein have shown that adding bulky adjuncts to cisplatin or using different platinum compounds varies the degree and extent of …
-
ROLE OF DNA DAMAGE RESPONSE IN LIVER REGENERATION AFTER APAP OVERDOSE INDUCED ALF
… (NAPQI) and it’s covalent binding to protein, oxidative stress, mitochondrial damage and subsequent nuclear DNA damage leading to necrosis. The replacement of necrotic cells and restoration of liver function occurs through liver regeneration. Although several studies have shown that …