Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Protein acylation"”.
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Regulation of The Expression and Lysine Acetylation of Pro-Inflammatory Molecules By Lipid-Modifying Enzyme (LPCAT2) in RAW264.7 Cells
… and receptor signalling. Regulation of protein acylation is also an integral mechanism for macrophage function. LPCAT2 influences acylation of proteins such as RNF19B – An E3 Ubiquitin Ligase. This research aims to understand further the molecular mechanisms of the enzyme – LPCAT2, that …
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The characterisation of calpain-like proteins in Trypanosoma brucei
… calpains and most of these novel calpain-like proteins are non-enzymatic homologues of typical calpains. The gene family is particularly expanded in ciliates and kinetoplastids, comprising 25 members in the parasite Trypanosoma brucei. Unique to kinetoplastids, some calpain-like proteins …
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Structural and Functional Insights into Ghrelin Acylation by Ghrelin O-Acyltransferase
… acts as the endogenous ligand for the GHSR1a G-protein-coupled receptor. This 28 amino acid peptide stimulates appetite and has been associated with the cardiovascular, gastrointestinal, neuroendocrine, and immune systems. Ghrelin requires a unique posttranslational modification to be biological …
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Lysophosphatidylcholine acyltransferase-2 (LPCAT-2) & protein S-acylation in macrophage innate immunity
… has been reported that LPCAT1 can catalyse the acylation of histone proteins. The addition of lipid groups to a protein can impact membrane-protein association, protein structure and protein stability ultimately affecting a proteins function. This gave rise to the main research question explored …
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Non-Lysine Acyl Modifications and Their Effects on Cellular Function
… our understanding of the scope and diversity of protein post-translational modifications has rapidly expanded. While mitochondrial proteins in particular have been studied in detail and are decorated with an array of acyl groups that can occur non-enzymatically, cytosolic proteins are also known …
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Ghrelin Processing and Maturation: Developing a Molecular-Level Framework for Hormone Activation and Biological Function
… an amine-substituted Dap residue at the site of acylation provided a superior system for exploring the molecular requirements for ghrelin recognition by GOAT. These studies have identified previously unidentified binding contacts and provides a comprehensive model of peptide binding in the hGOAT …