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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 107 for “"Protein abundance"”.

  1. Circadian and Circatidal Rhythms of Protein Abundance in the Intertidal Mussel Mytilus californianus

    Elowe, Cory2019

    … the dominant transcriptional rhythm. However, as proteins reflect the basic molecular phenotype of an organism and their abundance may differ greatly from that of mRNA, these methods could fail to detect important cyclical changes in the proteome that cope with the regular stress of tidal rhythms. …

    calpoly Repository record

  2. THE EFFECT OF SKELETAL MUSCLE-SYNTHESIZED BDNF ON MOTOR NEURON SOMA SIZE AND BDNF PROTEIN ABUNDANCE

    Benson, Sydney2025

    … signaling cascade that recruits dynein motor proteins for retrograde transport of the BDNF/TrkB endosome to the motor neuron soma. At the motor neuron soma, the BDNF/TrkB complex activates cyclic Adenosine Monophosphate (cAMP) response element binding protein (CREB), leading to transcriptional …

    nmu Repository record

  3. Effects of essential amino acids supply and body condition prepartum on antioxidant, inflammation and mechanistic target of rapamycin pathways in adipose tissue during the periparturient period

    Liang, YushengUniversity of Illinois at Urbana-Champaign2022

    … acid supply, can utilize them as fuels, or for protein synthesis regulated in part via insulin and mechanistic target of rapamycin (mTOR) signaling. Nuclear factor, erythroid-derived 2-like 2 (NFE2L2, formerly Nrf2) is a key transcription factor controlling cellular oxidative stress (OS) in …

    uiuc Repository record

  4. Induced Degradation of G-Protein-Coupled Receptors Through Proteolysis Targeting Chimeras

    Saca, Victoria2026

    <p>G protein-coupled receptors (GPCRs) are a family of heptahelical transmembrane proteins that can modulate various cellular signaling pathways and therefore are attractive drug targets. Despite high mutational rates of GPCRs in cancer there are few oncology FDA-approved anti-GPCR drugs, leaving a …

    rockefeller Repository record

  5. Digoxin and exercise effects on Na+,K+-ATPase isoform gene and protein expression in human skeletal muscle

    Gong, XiaofeiVictoria University2006

    … and Na+,K+-ATPase isoform expression and protein abundance in skeletal muscle of healthy individuals. Ten active, but not well-trained healthy volunteers (9 M, 1 F) gave written informed consent. Subjects performed incremental cycle ergometer exercise to measure VO2peak and to determine …

    vu-aus Repository record

  6. Functional investigation of PERIOD in the mammalian circadian clock

    Mihut, AndreiUniversity of Cambridge2023

    … by a feedback loop in which PER and CRY proteins form complexes that repress CLOCK·BMAL1-driven transcription of the Period (Per) and Cryptochrome (Cry) genes. Whilst Per clock genes are essential for circadian rhythmicity, little is known about the cell-autonomous mechanisms that confer …

    cambridge Repository record

  7. Effects of ractopamine hydrochloride on nutrient digestibility, environmental N excretion, regulation of skeletal muscle growth, and beta-receptor subtypes in finishing beef steers

    Harsh, Bailey N.University of Illinois at Urbana-Champaign2018

    … repartitioning agents, redirecting energy toward protein accretion and away from lipid deposition. Despite nearly fifty years of research, several questions still exist surrounding beta-adrenergic receptors and the agonists to which they bind. The primary objective of this research was to evaluate …

    uiuc Repository record

  8. Regulation of BubR1 by Ultraviolet Radiation: Implications in Skin Cancer

    Nlekwuwa, Peace RotachiCreighton University2023

    … cancer. BubR1 is an essential mitotic checkpoint protein that plays a critical role in regulating chromosome segregation and maintaining genomic stability. BubR1 dysregulation can lead to an increase in chromosomal instability and aneuploidy, a common phenomenon associated with most cancers. …

    creighton Repository record

  9. Acute and chronic heat stress alters the metabolic profile of skeletal muscle in growing swine

    Won, Samantha Gwai LanVirginia Tech2012

    … analyses. Differences (p<0.05) were observed in protein abundance of p-4eBP1 and total Rs6 and gene expression of Cox5B, CytB, EEF2, HK2, MURF, ND1, PGC-1α, SDHA, and TFAM during the acute heat stress study. Differences (p<0.05) were observed in protein abundance of 4eBP1, total Akt, and p-Rs6 …

    vt Repository record

  10. The perioperative setting as a platform for breast cancer biomarker development

    Hennessy, MaeveUniversity College Cork2024

    … digital spatial profiling (DSP) assessed immune protein abundance in intraepithelial and stromal segments. There was a significant association between intraepithelial HER2 protein abundance and pCR. Overall, the results demonstrated the unique molecular and immunological features of ER-negative, …

    cork Repository record

  11. Alterations in Uterine and Placental Sodium Pump Abundance May Contribute to the Onset of Mouse Labor

    Vance, Carlos Jacob2005

    … Reductions in sodium pump (SP) abundance can give rise to increases in contractile force in uterine and vascular smooth muscle as well as an increased secretion in secretory cells, including potentially those of the placenta. To determine whether the mouse might serve as a model …

    byu Repository record

  12. Regulation of Nutrient Metabolism in Equine Skeletal Muscle and Adipose Tissue

    Suagee, Jessica KanekakenreVirginia Tech2010

    … >1,000 mIU/L for six hours decreased transcript abundance of glucose transporters and the insulin receptor in adipose tissue, and decreased protein abundance of the insulin receptor in skeletal muscle, potentially indicating that hyperinsulinemia potentiates insulin resistance. Insulin infusion …

    vt Repository record

  13. Age-related changes in renal function, membrane metabolism, transporter activity and abundance in hypokalemic Fischer 344 x Brown-Norway F1 rats

    Eiam-Ong, SomchitTexas Tech University1998

    … (BBM) and basolateral membrane (BLM) protein and lipid metabolism, transporter activity and abundance were examined in non-obese male Fischer 344 x Brown-Norway Fl rats of 4 mo and 30 mo of age. These experiments were designed to examine whether age-associated changes occur in these …

    ttu Repository record

  14. Circadian Regulation of Protein Homeostasis

    Seinkmane, EstereUniversity of Cambridge2021

    … processes. In various models, rhythms in protein abundance of 10-20% of the proteome have been reported. However, regulation of these rhythms is not well understood, as most of them are not accounted for at the transcript or even ribosomal occupancy level. It is also unclear how circadian …

    cambridge Repository record

  15. The Influence of Chromium Supplementation on the Insulin Pathway, Carcass Traits, and Meat Quality of Feedlot Steers

    Rode, Heather2017

    … muscle (LM) biopsies were collected to examine protein abundance and gene expression after adaptation to a terminal implant and after adaption to ractopamine hydrochloride (RAC). A follow up study, Experiment 2, was conducted with yearling steers supplemented 0 ppb (CON) or 300 ppb Cr propionate …

    sdstate Repository record

  16. Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation

    Bartholome, Anne LouiseUniversity of Illinois at Urbana-Champaign2015

    … with TPN and found increased ileal mRNA and protein abundance of the brush border sodium-dependent glucose cotransporter, SGLT-1. However, the minimum effective dose that is necessary to enhance intestinal function is unknown. Therefore, GLP-2 was coinfused with TPN at three physiological …

    uiuc Repository record

  17. Understanding grapevine responses to abscisic acid

    Rattanakon, Supakan2015

    … analysis revealed 839 genes whose mRNA abundances varied significantly in different organs in response to ABA treatment. No single gene exhibited the same organ-specific changes in transcript abundance across all organs in response to ABA. The biochemical pathways affected by ABA were …

    unr Repository record

  18. Microrna involvement in hepatic adaption during the periparturient period in Holstein dairy cows

    Bucktrout, Ryan ElizabethUniversity of Illinois at Urbana-Champaign2019

    … miR-142 3p, miR-142 5p, miR-101, and miR-186 abundance via qPCR after normalization with 3 internal controls. Results indicated that MET cows had less expression of miRNAs that were predicted to downregulate oxidative phosphorylation and fatty acid metabolism, compared to CON. Considering that …

    uiuc Repository record

  19. Characterization of TvDMC1 and TvSOD6 expression and function in trichomonas vaginalis

    Foray, Nathalie Emma-Marie2018

    … studies have confinned the organism has meiotic proteins. These meiotic proteins are known to function in other organisms with a key protein in homologous recombination, DMCl. RT-PCR analysis shows low expression ofDMCl in mitotically-growing cultures, and we found that some stresses on the …

    u-pacific Repository record

  20. Micromanaging Freeze Tolerance: The Biogenesis and Regulation of microRNAs in Frozen Frogs

    Hadj-Moussa, HananeCarleton University2017

    … Immunoblotting was used to investigate protein abundance of key microRNA biogenesis factors in brain and liver of control, 24 h frozen, and 8 h thawed R. sylvatica. Biogenesis capacity was reduced in brains and elevated in livers during freezing and thawing. This correlated with RT-qPCR …

    carleton Repository record

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