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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Protein Subunits"”.
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Purification and Serological Comparison of Soybean Mosaic Virus and Its Protein Subunits
Made available in DSpace on 2014-12-14T04:37:41Z (GMT). No. of bitstreams: 1 7715019.pdf: 5869758 bytes, checksum: 0dfc16202a29d43f10301b39192003e3 (MD5) Previous issue date: 1977
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Studies on the structure and function of various nif and nif- associated gene products encoded within the Azotobacter vinelandii nif gene cluster
… of the metalloclusters present within the MoFe protein of nitrogenase from Azotobacter vinelandii. A gene replacement strategy was developed for oligonucleotide-directed mutagenesis of these proteins and the resulting biological and biochemical effects of these changes were examined. …
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The characterization of adaptor protein homologues in Plasmodium falciparum
… normal processes of parasite metabolism. Adaptor protein complexes are components of protein coats that associate with transport vesicles of the endocytic and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The presence of …
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Skeletal Muscle Adaption to 5 days of High-Fat Feeding in Humans
… Utilizing proteomic analysis of metabolic proteins in humans may lead to the mechanism behind skeletal muscle adaption to macronutrient composition, potentially providing the groundwork for characterizing the etiology of high-fat feeding induced metabolic disease. The objective of this …
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Dendritic cell maturation and activation via RNA/DNA danger signals : co-delivery of protein antigen with siRNA or CpG DNA
… against such foreign invaders. Recombinant protein subunits and peptides are relatively safe alternatives to live attenuated pathogens. However, these antigens are poorly immunogenic when administered alone in solution form and thus require the use of an adjuvant. To this end, we have …
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The role of podovirus-like bacteriophage in the virulence of Vibrio harveyi strain 47666-1
… and monoclonal antibodies specific to the toxic protein subunits of V. harveyi 47666-1. These antibodies were then used to detect this specific exotoxin from the previously naïve strains of V. harveyi infected with the phage VHPL. SDS-PAGE analysis showed an up regulation and production of …
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Impact of Low-Amylose, Waxy Wheat (Triticum Aestivum L.) Flour Blends on Functional Tortilla Characteristics
… flour in a blend resulted in increasing the mean protein content. Also, it increased water absorption, while it decreased dough consistency as determined using a Mixolab. Tortilla diameter and rollability were improved by the addition of low-amylose flour in the formulations; whereas, tortilla …
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Novel Modulation of Adenylyl Cyclase Type 2
… cyclase isoforms are distinctly modulated by G protein subunits and are therefore hypothesized to be uniquely regulated by proteins that influence G protein signaling. Activator of G protein signaling 3 (AGS3) is a G protein modulator that binds Gαi subunits in the GDP-bound state, implicating …
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Mechanisms of bacterial CRISPR immunity and a phage counter-defense
… memory is used to target CRISPR-associated (Cas) proteins to destroy the phage. In response, phages evolved anti-CRISPR proteins (Acrs) to inactivate this bacterial immune system. Since Cas nucleases can be programmed to target and cut specific genetic material, these molecular scissors have …
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Design and manufacturing of a physical model of an icosahedral virus capsid
… of three major components; developing the protein subunits that create the capsid, giving the subunits an appropriate mating angle, and joining the subunits to form the virus model. The subunits were created by two different approaches, through the use delrin, and through injection molding. …
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Characterization of Rimonabant effects on G protein activity
G protein-coupled receptor (GPCRs) is the largest class of cell-surface receptors, and represents today the target of 40% of the drugs in the pharmaceutical market. In the absence of agonists, many GPCRs have found to exhibit spontaneous activity, which can be blocked by ligands that are referred …
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Analysis of protein secondary structure via the discrete wavelet transform
… convert the primary amino acid sequence of the protein to a numerical signal using the hydrophobic tendencies associated with the amino acids. The data used in this project consists of both a + B and a/B proteins coming from the Structural Classification of Proteins (SCOP) protein database. …
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Photochemical ribonucleotide reductase for the study of proton-coupled electron transfer
… amino acid radical hopping pathway spanning two protein subunits.
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Changes in the Rpb3 Interactome Caused by the Deletion of RPB9 in Saccharomyces cerevisiae
… genes. Pol II is a complex composed of twelve protein subunits. This study focused on the changes in the interactome of Rbp3 in S. cerevisiae when the Pol II subunit Rpb9 is removed. Rpb3 is one of the core subunits of Pol II, and any significant changes to the Rpb3 incteractome due to the loss …
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Novel effects of Prefoldin Pathway on Intestinal Homeostasis via Dietary Restriction in Drosophila melanogaster
… My research explores the role of two protein subunits found in a complex which may have possible functions in the regulation of these processes. The overall complex is formed from six subunit proteins, some of which are known to assist in other cellular functions including cytoskeleton …
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Mechanistic investigation of coordinated conformational changes in multisubunit ion channels and enzymes
Many enzymes and ion channels consist of multiple subunits and/or multiple distinct functional components. Coordinated conformational changes through allosteric interactions between subunits and/or between functional units can efficiently regulate protein activity. This dissertation describes …
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In Vivo Regulation Of Transcription Of The Escherichia Coli Rna Polymerase Genes Rpo(b) And Rpo(c)
… genes rpoB and rpoC encoding b and b', the major protein subunits of E. coli RNA polymerase, was examined in vivo. Restriction fragments from the rplKAJLrpoBC cluster of genes were fused to a lacZ gene carried on a lambda phase vector. The transcriptional activity of each cloned fragment was …
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A Conserved epitope on the surface of carlaviruses
… A monoclonal antibody was raised to the coat protein of potato virus M which also reacted to other members of the carlavirus group. Viruses morphologically similar to carlaviruses but belonging to the potyvirus and potexvirus groups were also challenged with the PVM antibody, but failed to …
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Characterization of Protein Complexes and Protein Interaction Networks by Mass Spectrometry
… experimental proteomics approach for deciphering protein complexes and protein interaction networks in the budding and fission yeasts. Key steps of the employed analytical routine, including the purification of complexes and mass spectrometric identification of their subunits, were investigated in …
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Mechanistic studies of iron uptake into, and release from, Ferritins
… constitute a large family of iron storage proteins that are found throughout life, in bacteria, archaea, plants and animals. The newly discovered ferritin from the bloom-forming pennate diatom Pseudo-nitzschia multiseries is similar to other eukaryotic ferritins that contains a ferroxidase …
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