Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 62 for “"Protein S"”.
-
Enzymology of DHHC-mediated Protein S-Acylation
Protein <italic>S</italic>-acylation is the post-translational modification of proteins with long-chain fatty acids at cysteine residues via a thioester linkage. The most commonly attached lipid is 16-carbon palmitate, thus the process is often called palmitoylation. Unlike other lipid …
-
Lysophosphatidylcholine acyltransferase-2 (LPCAT-2) & protein S-acylation in macrophage innate immunity
… LPCAT1 can catalyse the acylation of histone proteins. The addition of lipid groups to a protein can impact membrane-protein association, protein structure and protein stability ultimately affecting a proteins function. This gave rise to the main research question explored in this thesis: Does …
-
The Role of Protein S-glutathionylation on Ca2+ Signaling in Cultured Aortic Endothelial Cells
… Ca2+ concentration ([Ca2+]i). An increase in protein S-glutathionylation is a common response to oxidative stress; however, the role of glutathionylation in Ca2+ homeostasis and Ca2+ signaling processes is not well understood. Diamide, a membrane-permeable oxidizing reagent, rapidly and …
-
Poly(A)+ RNA From Sheep Omasal Epithelium Induces Expression of a peptide Transport Protein(S) in Xenopus laevis Oocytes
… omasal epithelium contains mRNA that code for a protein(s) capable of proton-dependent di-, tri-, and tetrapeptide transport. This provides further evidence that absorption of peptides from the ruminant stomach is possible.
-
Development of an in-cell förster resonance energy transfer technique to study protein structure inside living cells
… fluorescence acceptors and donors within a protein or between two proteins inside the correct intracellular compartment of living cells. The successful achievement of this goal will allow us to obtain high-resolution structural information from a protein, one key step towards high-resolution …
-
Hledání fysiologického partnera proteinu Ddi2 (DNA damage-inducible protein homolog 2)
… buněčných procesů, a to nejen pro degradaci proteinů, je takzvaný ubikvitin-proteasomový systém. V něm hraje klíčovou úlohu ubikvitin, malý protein s jedinečnou schopností řetězit se. Buněčné proteiny, označené daným ubikvitinovým řetězcem a tím předurčené k degradaci, se dále dostávají do …
-
Multi-domain Protein Unfolding Pathway Studies by Single Molecule Techniques
<p>Large multi-domain proteins, which are ubiquitous in the proteomes in eukaryotic and prokaryotic organisms, still lack intensive studies on their folding mechanisms due to their complicated interactions between and inside of their domains. My work is broadly aimed at characterize folding …
-
Control of The Master Virulence Regulatory Gene Atxa In Bacillus Anthracis
… structural genes for the anthrax toxin proteins and biosynthetic operon for capsule are positively regulated by AtxA, a transcription regulator with unique properties. Consistent with the role of <em>atxA</em> in virulence factor expression, a <em>B. anthracis</em> <em>atxA</em>-null …
-
Tissue Distribution of a Peptide Transporter mRNA in Sheep, Dairy Cows, Pigs, and Chickens
… epithelium encoding for a peptide transport protein(s), a 446-bp cDNA fragment was cloned from sheep omasal epithelium RNA. The predicted amino acid sequence of this fragment was 85.8, 90.5, and 90.5 percent identical to rabbit, human, and rat PepT1, respectively. The fragment was …
-
Rapid turnover of McL-1 couples translation to cell survival and apoptosis
… death, indicating that the loss of short-lived protein(s) via proteasome-mediated degradation was responsible for cell death. Multiple observations demonstrated that cycloheximide induces cell death by activation of the intrinsic/mitochondrial pathway of apoptosis. Cycloheximide-induced cell …
-
Hexose Transport In L6 Rat Myoblasts
… to attempt to identify the glucose transport protein(s). Two polypeptides with apparent molecular weights of 94000 and 52000 were tentatively identified as components of the hexose transport system.;The activation of hexose transport by specific antibody was described and experiments were …
-
Der Einfluss von milder therapeutischer Hypothermie auf die Vorhersagekraft des Serummarkers S-100 Protein bezüglich des neurologischen Outcomes nach erfolgreicher präklinischer Reanimation
… hypothermia on the release of the astroglial protein S-100 post CPR in survivors of out of hospital cardiac arrest. METHODS: Prospective, observational study during a two year period, involving medical emergen-cy services and five collaborating hospitals at the city of Aachen. 70 patients were …
-
Modulation of calcium signalling in human sperm by nitric oxide
… agent). Dithiothreitol application, to reduce protein –SNO groups, rapidly reversed the actions of NO and GSNO on [Ca\(^{2+}\)]\(_i\). The effects of NO, GSNO and dithiothreitol on protein S-nitrosylation, assessed using the biotin-switch assay, closely paralleled their actions on …
-
The Conserved Oligomeric Golgi (COG) Complex Is Required for Normal Import of Fatty Acids in Saccharomyces Cerevisiae
… of the mechanism of trafficking of membrane proteins to peroxisomes. The work described in this document centers around one protein from Saccharomyces cerevisiae, Cog7p. Cog7p is part of the conserved oligomeric Golgi (COG) complex. Results describing a basic function of Cog7p were published …
-
Virulence associated functions and vaccine potential of the burkholderia mallei type three secretion effector BopA
… which is used to deliver bacterial (effector) proteins into host cells to modulate immunological and cellular responses. The intracellular survival of B. mallei within murine macrophage J774.2 cells requires the type III secretion system (TTSS), although the effector protein(s) involved are …
-
Validation of a novel expressed sequence tag (EST) clustering method and development of a phylogenetic annotation pipeline for livestock gene families
… were clustered into gene families using Ensembl protein family clusters as a framework. Following clustering, the EST consensus sequences were assigned predicted function by transferring annotations of the Ensembl vertebrate protein(s) they are grouped to after sequence homology searches and …
-
The regulation of blood coagulation by high-density lipoprotein particles
High-density lipoprotein (HDL) has anti-atherogenic properties and the plasma level of HDL cholesterol correlates inversely with the risk of coronary artery disease. The atheroprotective functions of HDL can be explained by its function in the reverse cholesterol transport. Blood coagulation is …
-
Regulatory Mechanisms in Innate Immunity
… among pathogen recognition receptors, adaptor proteins, kinases, and transcription factors that elicit the production of effector cytokines. As an important transcription factor, IRF5 was known to be essential for the host cytokine production in response to various ligands and SNPs in IRF5 have …
-
Role of c-Cbl in Invasion of Mammalian Cells by Rickettsia Conorii
… signals from a Rickettsia conorii cell surface protein called rOmpA. This ubiquitination event enables Ku70 and the attached bacteria to be endocytosed into the cell. [SPECIFIC AIMS] 1. To analyse the effect of c-Cbl - mediated ubiquitination on Ku70 localisation. We will investigate if …
Page 1 of 4