Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Protein Processing, Post-Translational"”.
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Development and Application of Proteomic Technologies for the Analysis of Post-Translational Modifications
Post-translational modifications represent a rapid and dynamic means for diversifying the chemistry of the ~20 ribosomally coded amino acids. As such, they provide an ideal mechanism for promoting cellular adaptability by facilitating the tuning of protein interactions and functions in response to …
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Exploring the Dynamics of Mechanosensitive Channels Utilizing a Post Translational Modification Approach
… it is still unclear how specific regions of the protein interact with the membrane, and how these interactions change upon channel gating. Here we hypothesize that during channel gating specific residues of MscL change their local environment. We investigate this hypothesis by using a …
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Biochemical and Cellular Characterization of NMN Adenylyltransferase 2: A Brain Specific Isoform of an Essential NAD Synthesizing Enzyme
… that Nmnat2 is a neuronal peripheral membrane protein anchored via palmitoylation that localizes to dendrites and the cell body. Furthermore, I argue that a low level of Nmnat2 in the axon, or possibly its exclusion altogether, is required for normal (i.e. fast) axon degeneration, providing a …
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Genetic Analysis of Fic-Mediated BiP AMPylation in Photoreceptors
… to maintain their function. The Unfolded Protein Response protects cells from the accumulation of misfolded proteins in the ER. Depending on ER stress levels, the ER-resident Fic protein catalyzes AMPylation or deAMPylation of BiP, the major ER chaperone. This work elucidates a critical …
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Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory
Protein phosphatase inhibitor-1 and cyclin-dependent kinase 5 (Cdk5) have been independently implicated in synaptic plasticity, learning, and memory. We began our studies with the identification, confirmation, and characterization of a novel Cdk5-dependent phosphorylation site (Ser6) on …
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Carbon Starvation Metabolically Regulates Chromatin for Transcriptome Rewiring
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Trimming Fat Upon Infection: Proteolytic Demyristoylation as a Novel Bacterial Pathogenic Strategy
… pathogens, Shigella injects effector proteins into an infected cell to control its responses. Dedicated type III secretion system delivers more than twenty effectors which highjack normal cell signaling by modulating activity of host proteins. By interfering with immune signaling, …
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The Regulation and Function of Drosophila Acinus
Autophagy and growth control are two processes critical to organisms that mutually antagonize and regulate on each other. Several well known connections between these processes have been described, but here I describe a new link. Using Drosophila melanogaster as a model system, my thesis research …
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Essentiality and Regulation of Deoxyhypusination in Trypanosoma brucei
… initiation factor 5A (eIF5A). Hypusination, a post-translational modification, occurs via two enzymatic reactions. First, deoxyhypusine synthase (DHS) transfers the aminobutyl moiety of spermidine onto the eIF5A-lysine generating deoxyhypusine which is then hydroxylated by deoxyhypusine …
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Safeguard of Mitosis: The Spindle Checkpoint
… sensing and checkpoint signaling. Of kinetochore proteins, the KMN network acts as both a critical microtubule receptor and a signaling platform for the spindle checkpoint. The human KMN contains the kinetochore null 1 complex (Knl1C), the minichromosome instability 12 complex (Mis12C), and the …
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Crosstalk Signaling Between cAMP and mTORC1
… to regulate anabolic and catabolic processes. G-protein-coupled receptors (GPCRs) paired to Gs proteins increase cyclic adenosine 3'5' monophosphate (cAMP) to activate protein kinase A (PKA), which phosphorylates Raptor at Ser 791 resulting in potent mTORC1 inhibition. We identified a novel …