Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Protein Palmitoylation"”.
-
Search For The Functions That Mediate Protein Palmitoylation And Depalmitoylation
<p>Protein palmitoylation is a critical regulator of protein location, function and activity in the cell. While it has been known for some time that proteins can have cycles of palmitoylation and depalmitoylation throughout their lifetime, a thioesterase responsible for mediating the bulk of these …
-
Regulation of filopodia dynamics is critical for proper synapse formation
… by the recruitment of proper postsynaptic proteins, however the precise function of filopodia remains controversial. Thus the goal of this study was to investigate the dynamics of dendritic filopodia and determine their role in the development of synaptic contacts. We initially define and …
-
Develoment and Application of Chemical Strategies to Study Protein Fatty-Acylation in Eukaryotes
<p>Reversible S-palmitoylation confers spatiotemporal control of protein function by modulating protein stability, trafficking and activity as well as protein-protein and membrane-protein associations. While it is evident that palmitoylation is regulated in vivo, mechanisms that mediate cellular …
-
Identification of novel palmitoyl acyl transferases and characterization of the role of Huntingtin palmitoylation in Huntington Disease
… receptors and associated synaptic scaffolding proteins. HIP14 (huntingtin interacting protein 14) is the first identified and characterized mammalian palmitoyl transferase that regulates this process. I have shown that HIP14 has striking effects on modulating trafficking and function of many …
-
Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell
… [ii] 2-Bromopalmitate, a classic inhibitor of protein palmitoylation, markedly attenuated cytokine-induced Rac1 activation, NOX2-mediated reactive oxygen species generation and inducible nitric oxide synthase-mediated nitric oxide release indicating that palmitoylation of specific G-proteins …