Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Protein Modification"”.
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Protein Modification and Degradation in the Cell Cycle of the Yeast Saccharomyces cerevisiae
… Ihre Aufgabe ist das Anbringen von Ketten des Proteins Ubiquitin, welches die Proteolyse am 26S-Proteasom auslöst. Die APC/C-Aktivität und dadurch auch die Zellzyklus-abhängige Proteolyse muss präzise reguliert werden, um die Abfolge von Schlüssel-Ereignissen zu gewährleisten. Das Ziel dieser …
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Systemic analysis of changes in protein modification and gene coexpression networks in cancer
Perturbed posttranslational modification (PTM) landscapes and gene expression networks commonly cause pathological phenotypes. To elucidate altered PTM landscapes on a large scale, disease-associated mutations from TCGA, Uniprot, and dbSNP were integrated with PTM sites from PhosphoSitePlus. We …
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Towards the development of a visible light-enabled histidine-selective protein modification strategy using diazo sulfonium-based probes
… -diazo sulfonium-based probes for the modification of histidine residues. Histidines represent attractive amino acid targets by virtue of their naturally low abundance but recurrent presence in protein active sites and pivotal biological roles. In addition, the design of a …
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Site-selective modification of cysteine residues
Proteins are biomolecules that carry out essential work in cells and are required for the structure, function, and regulation of biological systems. It is desired to install designer modifications on proteins of interest, in a site-selective manner mimicking nature's post-translational …
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Multifunctionalization of Proteins: Strategies for Combining Semi-Synthetic and Bioorthogonal Techniques
Proteins play important roles in biological processes including muscle movement, initiating immune responses, and memory formation. Full understanding of protein function requires determining its structure, assignment of function, and elucidation of interactions with other proteins or metabolites. …
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The Effects of Chemical Modification Upon Herbicide Binding in Thylakoid Membranes of Spinacia Oleracea (Spinach) and Amaranthus Hybridus (Pigweed), and The Photochemical Reaction Center of Rhodobacter Sphaeroides R26
… in this system is a novel one for this protein modification reagent.
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N⁶-formylation of lysine : a pathological secondary modification of proteins
There is increasing recognition that aberrant protein modifications play an important role in the pathophysiology of inflammation and oxidative stress in cells. We recently discovered that N⁶-formylation of lysine is an abundant endogenous modification of histone and chromatin proteins. The high …
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Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer
… result of many altered genomic, epigenomic, and protein modification states that contribute to a distinctive proliferative advantage. The same deregulations that initiate tumorigenesis of mammary epithelial cells are believed to coerce therapeutic resistance. On the other hand, population-wide …
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Bioorthogonal Chemical Reporters Reveal Fatty-Acylation of Histone H3 Variants and Cholesterol Modification of Proteins and Trafficking in Cells
… functions from basic building blocks to covalent protein modification and are particularly involved in signaling. Many rare and widespread human health concerns involve lipids but despite their importance, their analysis either free or protein-bound has remained difficult for decades. Here, using …
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Development and Application of Chemoenzymatic Tools to Investigate Site-Specific Protein ADP-Ribosylation
… sites on synthetic peptides and full-length proteins. Historically, chemical and topological complexities associated with ADP-ribosylation have stymied progress in this area. To overcome this, I have identified enzymes capable of: (i) installing ADP-ribose specific side chain functionalities …
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The characterisation of calpain-like proteins in Trypanosoma brucei
… calpains and most of these novel calpain-like proteins are non-enzymatic homologues of typical calpains. The gene family is particularly expanded in ciliates and kinetoplastids, comprising 25 members in the parasite Trypanosoma brucei. Unique to kinetoplastids, some calpain-like proteins …
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New perspectives on melanoma: The role of PAX3
… via alternate transcripts or posttranslational protein modification(s). Moreover, we consider its possible roles in melanoma and provide a comprehensive consideration of the significance of PAX3 expression in melanoma.
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Metal Mediated Mechanisms of Drug Release
… was further developed by the incorporation of a protein modification handle which allowed an amine-bearing drug to be covalently ligated to a protein by a palladium-cleavable linker. This chemistry was demonstrated by the conjugation of the anticancer drug doxorubicin to a tumour targeted …
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DNA enzymes for tyrosine PEGylation and azido-adenylylation of peptide and protein substrates
Proteins and RNA are used as enzymes in nature, while DNA is used for the storage and transfer of genetic information. Proteins and RNA are biopolymers that can fold into complex secondary and tertiary structures to enable substrate binding and catalysis. Given the structural similarity to RNA, …
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The Nonenzymatic Modification of Proteins by Steroids and DNA by Reducing Sugars; In Vitro and In Vivo Studies
… metabolites can react nonenzymatically with proteins to form covalent, addition products. An example of this type of reaction is the modification of hemoglobin A by glucose to form the minor species hemoglobin A<sub>1c</sub>. In this case, glucose reacts by forming a reversible Schiff base …
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Cellular responses to mechanical stresses applied via magnetic manipulators
… gene expression, post-translational protein modification, or cytoskeletal redistribution. Many studies of mechanotransduction explore the responses of cell populations to large and, occasionally, poorly characterized deformation. More recent techniques provide the means for …
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Manothermosonication (MTS) and pH-shifting combined treatment for modifying the functional properties of plant proteins: protein-stabilized nanocarriers and protection of docosahexaenoic acid (DHA)
Plant proteins are low cost, non-toxic, natural, biocompatible, and biodegradable polymers. In recent years, plant proteins have drawn increasing attention from the food and pharmaceutical industries as an alternative to animal proteins due to increased consumer concerns over the safety of …
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