Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Protein Microarrays"”.
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Development of protein microarrays for the investigation of host-pathogen interactions
… either based on crude whole cell lysates or glycoprotein preparations lacking high specificity and sensitivity. The work presented here investigates the humoral immune response to VZV infection in more detail, to better understand the mechanisms of the adaptive immune response to lead to improved …
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Exploring the complexities of the tissue microenvironment using high throughput protein microarrays
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Photonic Crystal Enhanced-Fluorescence and Label -Free Bioimaging
… DNA microarray capture spots. Applications to protein microarrays and cell-based assays are also demonstrated.
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Identification of surface protein complexes of Streptococcus pyogenes through protein microarray technology
… comprehensive understanding. The knowledge of protein complexes composition and structure could offer new, more effective targets for a more specific and consequently effective immune response against a complex instead of a single protein. Large-scale protein-protein interaction screens are the …
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Analysis of DNA-binding Proteins in Yeast Saccharomyces Cerevisiae
… involving the regulated interactions of multiple proteins with promoter and enhancer elements. A variety of approaches are currently used to study these interactions in vivo, in vitro as well as in silico. With the genome sequences of many organisms now readily available, a plethora of DNA …
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Enabling tools for biological analysis : technologies for the study of protein dynamics, detection and interaction
The study of proteins in biological systems requires a comprehensive approach: investigating dynamics, interaction and identification. This thesis will examine several technological approaches we have developed to address these needs. To enable the study of the dynamics of biological systems, we …
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Development and application of an antibody-based protein microarray to assess stress in grizzly bears (Ursus arctos)
… The objective of this work was to develop a protein microarray that could detect patterns of physiological stress in a rapid manner with small samples of grizzly bear tissue. Sampling from four regions in the foothills of the Rocky Mountains in Alberta resulted in the capture of 133 bears. …
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Role of Phosphorylation In The Regulation of Prmt5
<p>PRMT5 is a member of a group of proteins that mediate arginine methylation. It is involved in diverse cellular processes, including cell differentiation, splicing, transcription elongation and epigenetic silencing, and its expression is dysregulated in many cancers. Due to its pleiotropic …
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Application of silicon photonic microring resonators to the study of surface bioconjugation and protein capture agent binding kinetics
… estimated one million functionally distinctive proteins, a means for high-throughput analysis, such as protein microarray, is required for the identification and quantification of proteins from biological samples. Even though protein microarrays have been shown to be a powerful technique for …
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Design and optimization of ultrathin silicon field effect transistor's for sensitive, electronic-based detection of biological analytes
… or symptoms of illness. With cancer, RNA and protein biomarkers of cells are currently assayed to determine their serums level and if they have deviated from the normal ranges. However, these assays commonly require large centralized lab facilities, frequent monitoring during treatment, and …